Compound Baiji Gastric Retention Of Floating Sustained Release Tablets

The compound Sustained-release floating tablet which consisted of Rhizoma Bletillae, Berberine hydrochloride, Astragaloside and used to treat duodenum ulcer, gastric and gastritis. In this Chinese medicine, Rhizoma Bletillae is major medicine and others are minors. The Chinese medicine has targeting character and constringency hemostasis, clear heat, detoxification efficacy.The principle of this tablet was capable of remining buoyant on gastric fluid with prolonged gastrointestinal resident time which based on HBS ( hydrodynamically balanced system ). The tablet matrix is made of hydrophilic gel, its surface can bulging when touch the gastric fluid and then forms a kind of protective screen which can prolong the time of hydration and keep the density of tablet lower than content of stomach, which make the tablet floating on the gastric fluid. So the tablet will be remained in the stomach for longer time that more composition will be absorbed and the availability will be increased. The tablet made in this way is called "biological activity agent".We adopt super crush, absorb resin, hydrophile gelatin technology and orthogonal design method to optimize the formulation of the compound sustained-release floating tablet. We reviewed other factors which affected drug release of this medicine.According to the technology of ECT the process of tablet remained in stomach was observed. We select Berberine hydrochloride as index to observed pharmacokinetics and bioavai lability. The result shows Rhizoma Bletillae sustained-release floating tablet can float in the stomach. The optimized formulation was compared with normal tablet and the...