Medicine Liver Damage, Clinical Research And The Improvement Of The Diagnostic Criteria

Objective: The aim of this study was to analyze the clinical characteristics of herbal drug-induced liver injury(DILI) patients in recent five years, and might prove reference and improving for the diagnosis and cure the disease of herbal DILI.Methods:. A retrospective study was carried out on 60 patients who were considered as drug-induced liver injury in jiangsu province hospital of tranditional Chinese medicine in recent 5 years. There were total 50 patients according with Chinese diagnostic criteria for DILI, from DILI caused by west medicine were divided in group of A1, and those from DILI caused by herb in group of A2. The difference among the sex, time from treatment to liver injury, symptoms, serological examination, type of liver injury and prognosis of the patients were compared in SPSS 12.0 software respectively. The author modified the Chinese criteria, and compared the diagnosis of new criteria and old criteria on these 32 patients of herbal drug-induced liver injury.Results: The time from treatment to liver injury in the group A1 was 13.46±4.14d, and that in group the A2 was 21.96±5.33d, P<0.05. The frequency of acute cholestatic hepatitis in the group A1 was 30.8%, and that inthe group A2 was 45.8%, P<0.05. The modified Chinese criteria diagnosed 96.9% cases out of the 32 patents in jiangsu province hospital of traditional Chinese medicine as drug-induced liver injury, and the rate on the base of the old Chinese criteria was 75.0%, P<0.05.Conclusion: ①The clinical characteristics of herbal drug-induced liver injury patients have changed greatly:The time from treatment to liver injury was prolonged;The frequency of jaundice was higher than before. The frequency of acute cholestatic hepatitis was higher than before.②Chinese criteria can be...