Experimental Study On Treatment Of Drug-induced Liver In Detoxification Liver Soup

Objectives: To explore the efficiency of Jieduyanggan Soup in treating Drug-induced liver injury. Methods : Sixty healthy three-month-old Kunming mice were divided into six groups of ten as following:normal control group, model control group, high-dosage treatment group,middle-dosage treatment group,low-dosage treatment group, Huganpian positive control group. Expect group one, the other five groups were injected Paracetamol Suspension (150mg.kg^-1) in the abdominal cavity of the mice. Sixteen hours later, mice of group three, group four and group five were forced to take the Jieduyanggan Soup directly intostomach respectively according to the dosage of 3.33g/(kg·d),6.66g/(kg·d), 10.0g/(kg·d). Mice of group six were forced to take Huganpian aqueous solution (22.75mg/kg). Mice of group one and group two were fed the same volume of distilled water. Keeping these actions once per day for two weeks. After the last time of giving medicine, mice of each group were forbidden to eat for twelve hours. Then took the blood sample through the mice's abdominal aorta. Through the examining on the Drug-induced liver injury mice's ALT, AST, ALP, GGT, TBIL, ALB, A/G to explore the function of Jieduyanggan Soup on protecting liver, lowering GPT and preventing liver damage. Conclusion: Each dosage of Jieduyanggan Soup can lower the rising of the mice's ALT, AST, ALP, GGT, TBIL caused by Paracetamot Suspension,and can rise the mice's falling of ALB, A/G caused by Paracetarnol Suspension.The curing intensity id related to concentration and the statistics shows that the high-dosage treatment group has better curative than the others. All of above shows that Jieduyanggan Soup has an good effect on curing Drug-induced liver injury.