Strengthening The Economy And Activating Blood On The Impact Of Asthma In Patients With Inflammatory Factors

【Objective】To approach the possible mechanism of Gubenpingchuandecoction on the prevention and cure Of asthma patients, by clinicalobservation and reseach of the effect of Gubenpingchuan decoction toinflammatory factors such as cytokine IL-5, adherence factor ICAM-1, andthe level of airway reactivity of bronchial asthma patients.【Method】Total 62 patients whose final diagnosis was period of acuteepisode of bronchial asthma devided into the group of chinese traditionalmedical therapy and the control group of western medicinetherepy. Conventional therapy such as glucocorticosteroid,β₂-receptoragonist atomization inhalation were applied, clinical observation andemperical study and symptomatic treatment(chosing the dosage accordingthe graduation of patient's condition). Among the first 15 days of therapyperiod, glucocorticosteroid were not used, In therapy group,Gubenpingchuan decoction were added to the control theropy at equalpace, one dosis everyday, decocting with water and get 300ml of juice, twiceto take. Two weeks as a course of treatment in both groups. The changes ofcontent of IL-5 in peripheral blood of patients pre and post therapy inboth groups were detected by ELISA method, the changes of the contents ofICAM-1 befor pre and post therapy were detected by immuno-histochemistrymethod, the level of airway reactivity pre and post therapy in both groupswere detected by SpirolabⅡ-type AR radiometer. To compare the index preand post therapy.【Result】①Two groups effect comparison, the group of the treatedgroup is efficient for 93.7%. As the control group is 86.7%. The differencewas significiant between two grooups(P＜0.05)②About FEV₁�'�FVC, theGubenpingchuan decoction group was(1.26±0.8,3.03±0.9)before therapy,while the control group was(1.28±0.8,3.02±0.8). after therapy, theformer was (2.38±0.7,3.52±0.8), while the later was(2.04±0.7,3.40 ±0.7).③About IL-5 and ICAM-1 subgroup of the two groups: (1)About IL-5lymphocyte, the the Gubenpingchuan decoction group was(52.4±15.8)beforetherapy, while the control group was(55.7±19.8). After therapy, theformer was (26.1±8.5),while the later was(40.1±12.4). (2) About ICAM-1lymphocyte, the the Gubenpingchuan decoction group was (315.2±42.1)before therapy, while the control group was (316.3±49.4). After therapy,the former was (272.8±30.4),while the later was (278.7±32.8). Onlythe comparative counting of IL-5 and ICAM-1 lymphocyte in theGubenpingchuan decoction group before therapy and after therapy wassignificantly different (P＜0.05), while others were not significantlydifferent. Only the comparative counting of IL-5 and ICAM-1 lymphocytein the placebo group was significantly different after therapy(P＜0.05),while others were not significantly different.【Conclusion】The Gubenpingchuan decoction could obviously improvethe clinical symptoms and physical signs of asthma patients, lighten thetoxic-side effects of the drugs, and elevate the absolute number, whilecould not effect the content of all kinds of cytokines of asthma patients.