| Object:Psoriasis is a chronic inflammational and hyperplasia dermatosis, theetiopathogenisis is uncertain and it's attack rate is high.which is 0.123% in china, the therapy isalso difficult., and affect the life quality of the patients.the etiopathogenisis of psoriasis is verymultiplicity, it refers to immunity, inflammation cell multiplication and apoptosis, capillary aswell as nerve factors under the polygenic inheritance background. among the total.The theory of immunity-inflammation net is generally accepted, it is believed that psoriasisis a T-ceil abnormal immunity-inflammation disease under the polygenic inheritancebackground.it manifestate mainly on the abnormity of T-lymphocyte subgroup and the release ofinflammatory factor such as TNF-αand IL-6.Psoriatic arthritis is also called arthropathic psoriasis, which is one type of psoriatic, itmanifestate ereuth, swell, heat and pain besides typical skin lesion clinically.It is a speciesimmunity inflammational arthritis.it is studied that arthritis is comparatively frequent in thepsoriatic, not ontythe incidence rate is about 6.8% but also the Mutilation rate is high, whichseverity effect patient's quality of life. Psoriatic arthritis medical cure is main to useanti-inflammatory and immunosuppressive drug; which includ non-steroidal anti-inflammatorydrug, glucocortieoid, immune depressant and anti-rheumatism. But people come to pay moreand more attention to the by-effects of these medicine after long-term use.It has becomed warmspots to exploit utility and low by-effect herb recently.Rheumatoid Arthrits and psoriatic arthritis are both immunity inflammational arthritis,which both belong to arthromyodynia category in Chinese medicine.A bulk clinical researchindicate that traditional Chinese medicine have a certain effect on Rheumatoid arthritis.According to the axiom of homotherapy for heteropathy in traditional Chinese medicine,Psoriatic arthritis and Rheumatoid arthritis fairly resemblance in the etiological factor andsymptom, and also a great of drug are general for them clinically such as Cyclosporin A,methylaminopterin, Tripterygium Glycosides and so on. we suppose that the drug which can treatrheumatoid arthritis may can also treat psoriatic arthritis. We progress researched in thissuppose, and supply experiment evidence.Method: To choose SD rat as experiment obiect, which was divided in to 5 groups: normal control group, model group, methylaminopterin-treat group, tripterygiumglycosides-treat group, and GuiZhiShaoYaoZhiMuTang-treat group, establishing immunityinflammation rat model., through measuring rat voix pedis intumesce degree, the content ofIL-6, TNF-A in peripheral blood, and rat's weight as well as organ index, we can observe theeffect of GuiZhiShaoYaoZhiMuTang for treating adjuvant-induced arthritis rat and theby-effect.Consequence1 The influence to rat arthritis index AI: on the 4th and 8th day post-administration, compare tothe model group, the AI of rat in GuiZhiShaoYaoZhiMuTang group decrease significantly,(P＜0.05), but there is no statistics difference(P＞0.05)compare to other groups.2 The influence to the voix pedis tumidity extent of rat: each Medication group have manifestdecrease after last administer, and compare to model group there is statistics difference(P＜0.05), but no statistics difference exsit in Medication groups (P＞0.05).3 The influence to the content of IL-6, TNF-A in rat's peripheral blood: the content ofIL-6, TNF-A in GuiZhiShaoYaoZhiMuTang group significantly lower than model group(P＜0.01), and have no statistics difference compare to other treat groups (P＞0.05).4 The effect on rat weight: after administer for eight days, the weight augmentation ofrat in model group, MTX group and tripterygium glycosides group is significantly lower thannormalcontrol group compare to it before administer(P＜0.01), and GuiZhiShaoYaoZhiMuTanggoup increase significantly compare to other treat group (P＜0.01), have no significancedifference compare to normal control group(P＞0.05).5 The effect on organ index :GuiZhiShaoYaoZhiMuTang have littler suppression effecton thoracic gland and adrenal gland compare to MTX group and tripterygium glycosides group.condusiion1 GuizhiShaoYaoZhiMuTang can lessen the voix pedis swell grade and arthritis index ofadjuvant-induced arthritis rat.2 GhiZhiShaoYaoZhiMuTang can significantly cut down the contents of IL-6 and TNF-a in adjuvant-induced arthritis rat blood serum, have no significance difference compare toother treat groups. This may be one of the mechanism to lessen the voix pedis swell gradeand arthritis index3 To observe the adjuvant-induced arthritis rat weight and organ index, which displayGuiZhiShaoYaoZhiMuTang's by-effect is lowest in the treat groups, and have lesssuppression function to important organ such as thoracic gland and Adrenal. |
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