| Headspace gas through the sample matrix analysis is the top of the gas composition of these components to the original content in the sample,The basic theory is based on under certain conditions, the gas and condensed phase (liquid and solid-phase) balance exists between the distribution of they. Therefore, the composition of gas reflects the condensed phase composition. Headspace analysis can be seen as a kind of vapor extraction method. That is, gases do "solvent" to extract samples of volatile components, As a result, headspace analysis is an ideal sample purification methods.Drugs in the mean residual solvents in pharmaceutical raw materials or vested in the production of the agent, Preparation and in the preparation process of the production or use of volatile organic compounds, which can not be fully in the process of it. In the synthesis of pharmaceutical raw materials in the selection of appropriate solvents can increase production or decide the nature of drugs, such as crystal, purity, such as solubility.However, no organic solvents and potentially therapeutic effect on human health and environmental hazards, it is necessary to have a choice to use.At present, China's pharmaceutical raw materials on various residual organic solvent has not built a uniform quality standards, not included in USP, The experiment meloxicam, clindamycin phosphate, pantoprazole sodium three raw materials in organic solvent residues entering the establishment of standards for quality in-depth study. 2010 Pharmacopoeia for pharmaceutical raw materials added some organic solvent residue and provide a reliable, effective data. |
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