| Objetives: To observe the effect of Xinfukang(XFK)oral liquid on hemodynamics,cardiac function and the content of energy metabolism material in the rat model of Heart Failure post Myocardial Infarction.Methods: The AMI models were established by ligating left anterion descending coronary artery and the rats with AMI were ramdonly divided into Sham group,Model group,Captopril group ,Yiqihuoxue chinese medicine into XFK high dose group and XFK low dose group.Twenty-four hours after establishing models the rats were fed on XFK oral liquid through the gastrotube for 8weeks. Captopril group was serrved as control,After 8 weeks of the treatment,Hemodynamics,cardiac function and the content of energy metabolism material were measured.Results:(1) The effect of Xinfukang(XFK)oral liquid on hemodynamics of Heart Failure post Myocardial Infarction in rats Contrast with sham group, diastolic blood pressure in model rats was lowered, with statistically significant difference (P<0.05),heart rate and blood pressure change were not significant (P>0.05);compared with model group, heart rate and diastolic blood pressure changes were not statistically significant both in XFK group and Captopril group,but systolic blood pressure in Captopril group was decreased significantly,with statistically very significant difference (P <0.01)。(2) the effect of Xinfukang(XFK)oral liquid on cardiac function of Heart Failure post Myocardial Infarction in rats Contrast with sham group,left end-diastolic pressure(LVEDP) was obviously increased , left ventricular systolic pressure(LVSP),cardiac output(CO),as well as maximum rate of rise and fall of left systolic pressure(+dp/dtmax,-dp/dtmax) in model group were signififcantly decreased,with statistically very significant difference (P <0.01).Compared with model group,left end-diastolic pressure(LVEDP) was obviously decreased , left ventricular systolic pressure(LVSP),cardiac output(CO),as well as maximum rate of rise and fall of left systolic pressure(+dp/dtmax,-dp/dtmax) were signififcantly increased in XFK group and Captopril group,with statistically very significant difference (P <0.01).(3)The effect of Xinfukang(XFK)oral liquid on the content of energy metabolism material of Heart Failure post Myocardial Infarction in rats Compared with sham group,the contentl of ATP in left ventricular muscle was obviously decreased,but ADP and AMP were significantly increased in model group(p<0.01).Compared with model group ,the content of ATP was obviously increased in XFK oral group and Captopril group,but ADP, AMP were significantly decreased,with statistically very significant diference(P <0.01).Conclusion:(1) XFK oral liquid can effectively reduce LVEDP, increase LVSP of Heart Failure post Myocardial Infarction in rats,but has no effect on SBP and DBP,thus to improve hemodynamics steady in rats with heart failure post Myocardial Infarction.(2) XFK oral liquid can effectively improve -dp/dtmax,+dp/ dtmax,and CO, so as to improve left ventricular systolic and diastolic function in rats of heart failure after myocardial infarction.(3) XFK oral liquid can effectively improve the content of ATP ,reduce the content of AMP and ADP in left ventricular muscle,thus improve energy metabolism disorder of heart failure after myocardial infarction in rats, in order to protect cardiac function. |
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