Studies In Peripheral Blood Of Mmp-7 Mrna Expression And Esophageal Cancer Metastasis Recurrence And Prognosis

Purpose:To evaluate the expression of matrix metalloproteinase - 7mRNA and its clinical significance in recurrence,metastasis and prognosis for patients with esophageal carcinoma.Methods:The MMP-7 was measured by using real-time quantitative reverse transcriptase-polymerase chain reaction during the follow up in 82 patients with esophageal carcinoma.The outcomes were then compared with 40 controls.Results:Among 82 cases,the positive rate of MMP-7mRNA was 37.8%.MMP-7mRNA expression was significantly associated with lymph node metastasis,blood metastasis and clinical stages.For 28 recurrent patients,we monitored 15 cases for 3 months of the average follow up.The MMP-7mRNA expressed previous to the imaging diagnosis for 3 to 6 months in five patients,it appeared in the same time in eight of them and two cases did not expressed MMP-7mRNA when imaging diagnosis were made.Conclusion:The expression of the MMP-7mRNA through RT-PCR is a sensitive and specific predictor in the recurrence,metastasis and prognosis for patients with esophageal carcinoma.It can provide reliable evidence in making treatment plan.