The Immunopathogenesis Of Idiopathic Inflammatory Myopathies Progress

Inflammatory myopathies (IM) are a group of conditions characterized by the presence of inflammatory infiltrates in skeletal muscle, usually in association with muscle fibre destruction. They are the commonest acquired myopathies. The etiology is unknown of most subtypes expect the infective myositis, so they are also called idiopathic inflammatory myopathies(IIM). Polymyositis(PM), dermatomyositis(DM) and Inclusion body myositis(IBM) are the three major clinical patterns,and the rare patterns are focal myositi(sFM)and so on. Muscle biopsy and pathology analysis are important methods to make a definite diagnosis. The etiological factor and pathogenesis of IIM are concerned with infection viral, hereditary factor, humoral immunity, cellular immunity, MHC expression, autoantibody, cytokine, adhesion molecule, apoptosis and so on. Previous study show that the infection viral and genetic sensitivity maybe the important initiating agent, PM is T cell mediated, DM is humoral immunity mediated autoimmunity disease. IBM is concerned with immunologic abnormality and myofibrosis. The MHC express in muscle fibers, various kinds of cytokines, adhesion molecule have import function to activated the T cell, regulated the immune response and mediated inflammation reaction. There are important significance to clarification the immuopathogenesis for study the etiology, diagnosis the subtypes and improve the clinical treatment effect. Nowadays, it is the focus of international study about the immunopathogenesis of IIM.