| Objective:To investigate the clinical efficacy adverse reaction and safety of Ping Xin Wang You Capsule in treating depression discuss relation of 5-H1AA in urina and depression proving the Capsule of Ping Xin Wang You to depression has a good therapeutic efficacy.Methods:The randomized controlled trial was conducted in 32 Patients in the treatment group and 31 Patients in the control group treated with Citalopram Hydrobromide.The efficacy of treatment was evaluated before treatment and one month after treatment,with Hamilton depression ratingscale(HAMD),the adverse reaction was assessed by Asbegr Rating Scale(ARS).The 5-HIAA's level in urine of these Patients was measured before treatment and one month after treatment.Diagnostic criteria(DC)1 Western medicine DCRefer to the classify ofalleosis and DC in Chinese of the third edition(CCMD-3), constitute of depression paroxysm.The downcast mood s is the major of symptom standard and at least it has four items:(1)hebetude no delight;(2)energy droping or tiredness;(3)the spirit motility lagging or agitation;(4)the self evaluation is lower,self-accusation,or guilt;(5)association is difficult or self-feeling the ability of considerion is dropping;(6)it often appears the idea of wangting to die or wangtting to suicide autolesion;(7)sleep disorder such as insomnia,dysphylaxia,or Sleeping more;(8)appetite brings down or body weight clearly alleviate;(9)sexual desire decline;Serious standard:The social function is impaired,making self distress or adverse sequence. The course of diseases standard:(1)fitting the symptom standard and serious standard is at least being two weeks,(2)It maybe exists some fissile symptom,but it is not accord to rent clastic symptom of diagnosis,if it is accord to rent clastic symptom of diagnosis,after rent clastic symptom relieving,suffice two weeks of depression happening,2 The Chinese medicine DCConsulting the Chinese indigenous hat medicine and Chinese indigenous Int illness diagnosis and treat rule:(1)main symptom;lasting mope,Emotional lability,anguish and depress;or guilt.(2)minor symptom:Insomnia and amnesia,headache and giddiness,heart-throb,exhaustion,inappetence,hypaphrodisia,unapprehensive and so on.(3)Usually introvert,there are depressed emotion's medical history of being more grief,anxietas,dread,detest and so on,in the near future,and there is closely correlation between the reduplication of pathogenetic condition and emotion,it may have family medical history.(4)All systematic inspection and laboratory examination are normal,except of organic disease.Aforesaid(l),(3),(4)are necessarily,it may be diagnosed if it has two termes. Depletion standard:Deplet organic alleosis,or the depression of cerebrationsubstancean and independence substanceanResults:The best times of therapy is 30 days,the longissimus is 180 days, Commonly dose 4～7 days,simultaneous phenomenon relief or disappear, pleasurable,mood stabilize,Forget the former grief and bother,diet and sleeping gradual improved(1)The population curative effect evaluate:treatment group:recovery rate 28.89%,patency improvement rate 37.78%,improvement rate 17.78%,the population availability rate 84.44%,t docimasia,p＜0.05,indicate the prescription has a obvious curative effect.Control group:recovery rate 13.33%,patency improvement rate 31.11%, improvement rate 22.22%,the population availability rate 66.67%,t docimasia, p＜0.05,indicate the prescription has a obvious curative effect,Two group have been t docimasiaed,p＜0.05,the treatment group surpass surpass the Control group.(2)The integration of traditional Chinese medicine symptom treatment circa:the integration of treatment group before curing:40.53±2.89,the integration of treatment group after curing:18.90±2.75,equation 22.63±2.98;Control group:the integration of treatment group before curing:39.50±2.71,the integration of treatment groupafter curing:22.83±3.52,equation 16.67±3.12.t Docimasiaed,p＜0.05, treatment group is better than Control group at symptom improved.Two groups compare on Traditional Chinese Medicine main symptom and tongue and pulse tracings before curing and after curing,it shows that curing group has some advantage on improving Traditional Chinese Medicine main symptom and tongue and pulse tracings.(3)Equation Control of two group patients' between before and after curing at HMAD integration altogether:treatment group:16.36±3.18,Control group 20.15±3.23,t Docimasiaed,p＜0.05,treatment group is better than Control group at HMAD,(4)Equation Control of two group patients' between before and after curing at many factors: Treatment group Control group anxietas factor:2.13±1.54 2.45±1.32 body weight factor:0.57±0.21 0.51±0.24 acknowledge factor:0.60±0.49 1.64±1.33 day and night factor:0.60±0.49 0.62±0.53 blockage factor:3.06±0.89 2.87±0.88 sleep factor:3.93±0.82 3.23±0.95 despair;factor:3.13±0.56 3.23±0.76t Docimasiaed,p＜0.05,treatment group is better than Control group at HAMD factors;Equation Control of two group patients' between before and after curing at 5-HIAA's concentration in urine,treatment group:1.76±1.73,Control group 0.99±1.99,t docimasiaed,p＜0.05,treatment group is better than Control group. (5)Control of two group patients' between before and after curing at Asberg's score,t Docimasiaed,p＜0.05,treatment group is better than Control group.Conclusion:There is patency curative effect of Ping Xin Wang You Decocton oncuring depression,side effect is little,the research proves that Ping Xin Wang You Capsule treatment depression by elevating 5-HIAA's concentration,and Ping Xin WangYou Decocton is better than Xi Pu Miao at many factors,... |
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