Stereotactic Conformal Radiotherapy For Liver Metastases Clinical Efficacy Of Multivariate Analysis

Objective:To explore the prognostic factors affecting the survival of patients with liver metastasis treated by three-dimentional conformal radiotherpy.Material and Methods:39 patients who presented with livermetastasis were treated by three-dimentional conformal radiotherpy.Lesion primaries were 25 patients received chemotherapy before radiotherapy.All patients uderwent three-dimentional conformal radiotherapy.Delivered in 12-30 fractions at 2-5Gy/f using a stereotactic frame.A dose of 52-68Gy/3-5weeks,mean dose is 61.54±5.94Gy.SPSS12.0 was used for Data-analysis.Kaplan-Meier actuarial survival curves for all prognostic factors were calculated. Survival curves of subsets were compared by Log-rank test.The possible prognostic factors were analyzed by univariate analysis and muti-variate analysis with COX proportional hazard model.Results:All patients were followed untill death or for a median of 19(8-28) months after three-dimentional conformal radiotherpy.Overall patients median survival time were 14 months,The significant prognostic factor demonstrated by univariate analysis included radiation therapy dose(p=0.0061),chemotherapy(p=0.0031),diameter of turnor(p=0.0070) ,number of Tumor(p=0.0245),site of tumor(p=0.0360), KPS(p=0.0070), radiotherapy-time(p=0.0187). According to multivariate analysis the independent prognostic factors were radiotherapy dose(p=0.0016) and chemotherapy(p=0.0011).Conclusions:Three-dimentional conformal radiotherapy is the effective treatment of liver metastasis.Radiotherapy dose and chemotherapy are the independent prognosticfactors of those patients.