Hovenia Dulcis Decoction On Hyperlipidemic Rats Ldl-c, Hdl-c In Experimental Research

Purpose: Through observation of animal experiments Hovenia dulcis Thunb decoction in hyperlipidemic rats LDL-C, HDL-C of the impact, and pharmacodynamics and safety of the study further defined the traditional Chinese medicine in the treatment of hyperlipidemia has its unique advantages.Method: Healthy Wistar rats were randomly divided into 6 groups Hovenia dulcis Thunb decoction of low-dose group, Hovenia dulcis Thunb decoction Medium dose group, Hovenia dulcis Thunb decoction high dose group, Xuezhikang group (positive control group), blank control group and model groups, each 10.Besides the blank group, gives the high fat feed to duplicate the high blood fats big mouse model 14 days, under the empty stomach eye socket vein draws blood, after makes the mold success explicitly, enters the treatment stage, The blank group and model group were given distilled water by gavage 1ml/100g remaining group were given high, medium and low doses of Hovenia Dulcis Thunb decoction and Xuezhikang 1ml/100g suspension by gavage,28 days later, the empty stomach abdomen aorta draws blood, observes high blood fats big mouse blood serum LDL-C, the HDL-C content change.Result: Hovenia dulcis Thunb and XUEZHIKANG decoction can reduce the experimental hyperlipidemic serum LDL-C levels and improve experimental hyperlipidemic serum HDL-C level:Model group and Hovenia Dulcis Thunb decoction of low-dose group were statistically significant(P<0.05),Model group and Hovenia Dulcis Thunb decoction Medium dose group, Hovenia Dulcis Thunb decoction high-dose group, Xuezhikang group has a high degree of statistical significance(AreP<0.01),Hovenia dulcis Thunb decoction of the middle-and high-dose group and Xuezhikang group, no statistical significance(AreP>0.05)Conclusion: Hovenia dulcis Thunb decoction can be safe and effective in treating hyperlipidemia, lipid-lowering effects and Xuezhikang equivalent, and a dose-dependent relationship.