Prodrug Acetyl Ferulic Acid Phenylpropanol Ester Synthesis Process And Pharmacological Effects

Ferulic acid is distributed in abgelica,equisetum and other Chinese herbal medicine which haves Pharmacological activity widely. Phenylpropanol also named as Lidan alcohol,with be useful of gall ,protecting liver cells and improving liver function. Phenylpropanol is a efficient Bile-Promotion angent and a moderate antispasmodic Pharmacy.This Subject will make liver-protection sodium ferulate and gall-benefit Phenylpropanol mosaic a Precursor drugs phenylpropanol ester acetylferulate. Then study and improvesynthesis process comprehensively. Finally Phenylpropanol ester Acetylferulate was given to the rats with liver injury induced by CCl₄ to study the pharmacology activity.1. Synthesis of phenylpropanol ester acetylferulate.First chloride, benzene and C by Fu - g acylation of a benzene acetone, and then tetrahydro boron potassium as a catalyst to further reduction in the benzene acetone Phenylpropanol. Then vanillin as raw materials, the synthesis of acetylcholine response perkin ferulic acid, and after further chloride to esterification Phenylpropanol Synthesis of phenylpropanol ester acetylferulate. Structure by IR, NMR, MS confirmed its structure. 2 . Acute liver injury in mice on the protective effect of phenylpropanol ester acetylferulate.Carbon tetrachloride to acute liver injury in mice model to sodium ferulate and Lidan alcohol as a positive control, observation phenylpropanol ester acetylferulate high, medium and low doses of three different pharmacological effects. The results showed that acetyl ferulic acid ester can Phenylpropanol liver injury in mice liver tissue MDA, serum ALT, TBIL was significantly lower, suggesting that acetyl Phenylpropanol ferulic acid ester with better pharmacological Hugan Lidan role, and its role better than sodium ferulate and Lidan alcohol.