| Objective:To study the nerve roots topical inflammatory factor change of cervical spondylosis rabbit model with drug intervention,the mechanism of cervical spondylosis NO.1 capsule for nerve roots topical inflammatory factor of rabbit model were explored to study the pathogenesis of cervical spondysis,which supply experimental basis for cervical spondylosis NO.1 capsule on treatment of cervical spondylosis.Methods:46 adult rabbits were divided into false operation group, model -making group and normal group,to establish the model by the methods of Peng bao gan and Yu jia kuo's which resect the cervical supraspinous and interspinous ligaments.2 months after the the models were established,The model-making group were divide into medicine group and normal model group,in which the medicine group were intervued by medicine and other groups were intervued by Sodium Chloride.Then the content of rabbits topical nerve roots inflammatory factors such as E2(PGE2),6-K-PGF1a,HE were examined and comparaed by the method of radioimmunity after treated 2w 4w and 6w.Result:1.The content of rabbits topical nerve roots inflammatory factors in cervical spondylosis NO.1 capsule group were significantly lower comparaed with normal model group(P＜0.01)2.The model estebilsh methods of Peng bao gan and Yu jia kuo has lower mortality and high effective power of detection,and has significant difference in statistics comparaed with false operation group and normal group(P＜0.01)Conclusion:1.Cervical sponddylosis NO.1 capsule can limit the nerve roots topical inflammatory factor of rabbit model effectively,compared with normal group,the effect is exactly obvious.2.Inflammation is the main reason of cervicodynia and lumbodynia caused by pathological changes of discus.and also has relationship with autoimmunity3.The model-making method of Peng bao ganYu jia kuo is a good method witch consistent with the mechanism of cervical spondylosis... |
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