| of Klebsiella pneumoniae in our hospital,we will analyse the age,specimen source,average daily hospital charges and antibiotic resistance rates between ESBLs-producing and non-ESBLs-producing Klebsiella pneumoniae group. So we can provide a scientific evidence for the reasonable use of antibiotics,delaying the bacterial drug resistance, and the effective control of the infection of Klebsiella pneumoniae, especially the epidemic of ESBLs-producing Klebsiella pneumoniae.Method:Infectious specimens from the hospitalized children in Dalian Children's Hospital from January 1, to December 31,2009 were collected. Bacteria was identified strictly according to the "National Clinical Laboratory Procedures". ESBLs positive strains were tested by phenotypic confirmatory test recommended by CLSI, Antimicrobial susceptibility was determinded by K-B method. The 162 strains of Klebsiella pneumoniae were divided into two groups,ESBLs-producing group and non-ESBLs-producing group. The statistical description and analysis of sex, age, specimen source, hospital costs and resistance rates was made.Result:In 2009,the prevalance of Klebsiella pneumoniae was 37.8% in the total isolates from hospitalized children,the ESBLs-producing strains accounted for35.2%;Rsepiratory infection was the main disease;Most of the children were infants under 1 year old;Strains isolated from throat swabs and sputum samples accounted for 87% of all samples;The average hospital stay of ESBLs-producing group was 12 days, the average daily hospital charges of this group is 578.6 yuan;while the average hospital stay of non-ESBLs-producing groupwas 8 days,the average daily hospital charges of it was 417.5 yuan.None was resistant to meropenem in Klebsiella pneu-moniae.The resistance rate of ESBLs-producing group toβ-lactam antibiotics without inhibitors was more than 90%,while the resistance rate of non-ESBLs-producing group to cephalosporins was 2.6%-23.1%.Conclusion:1.The infection of Klebsiella pneumoniae is common in our hospital.2.We should focus on respiratory infection caused by Klebsiella pneumoniae in infants less than 1 year old.3.The resistant of ESBLs-producing Klebsiella pneumoniae is serious,we should make a surveillance of it.It's important to use antibiotics reasonably according to the result of susceptibility test,and to control the spread of ESBLs-producing Klebsiella pneumoniae... |
