Measurement Of Lung Function And Clinical Comparison Study Of Msct Lung Volume And Airway

COPD is a disease state characterized by airflow limitation that is not fully reversible. COPD is a harmful disease to the human being's health which causes death and disability.The study is to investigate the correlation between MSCT in measuring lung volume, airway parameters and pulmonary function test. PFT results include FEV1, FEV1/FVC and MMEF. The study collects 20 CT images of COPD patients. Firstly, we segment the lung parenchyma using eight neighborhood boundaries tracking, and calculate the inspiration volume Vi, expiration volume Ve, Vi-Ve and Ve/Vi. Secondly, we extract airway luminal using region growing, and calculate the luminal area from the third to the fifth generations of bronchi (inner diameter≥2mm). Thirdly, according to the FWHM method, we can calculate the wall thickness and thickness-to-diameter ratio of these bronchus. Correlation between these parameters and PFT results were evaluated.The statistic results showed that Vi-Ve, Ve/Vi were significantly correlated with PFT results. The correlation coefficients between airway luminal at expiratory CT and PFT results were higher than those for inspiratory CT, and improved as the airway size decreased from the third to the fifth generation. The TDR5 and FEV1 were negatively correlated. Vi-Ve, Ve/Vi and EA5/IA5_B1 have positive meanings to the grading of COPD.