Observation Of The Clinical Efficacy Of Radix Sodium Chloride Injection In The Treatment Of Angina Pectoris (qi And Blood)

Purpose:To evaluate efficacy of Astragalus Membranaceus. Total Saponins Sodium Chloride (AMTSSC) Injection on Coronary Heart Disease Angina Pectoris with TCM syndromes of Qi deficiency and blood stagnation through clinical trial.And discuss its mechanisms.Material and method:1 Clinical Date: Select 70 cases with the diagnosed TCM syndrome of Qi deficiency and blood stagnation for observation .All of the involved cases were divided into two groups- Treatment Group,n=35;Control Group n=35. The 2 groups were comparable due to the statistical P>0.05 in comparisons in general data, TCM symptoms and laboratory examinations, which indicated no significant difference.2 Drug Administration:l00ml Per bottle AMTSSCI injection was given to Treatment Group intravenously for one time each day. The Control Group was given 1O0ml Per bottle tetramethylpyrazin hydroehloride in sodium chloride injection intravenously for one time per day, along with Astragalus injection 10ml per bottle mixed with 0.9% NaCl injection one time each day. Both groups received 2 weeks treatment. Medicines for CHD except nitroglycerin were prohibited during the trial.3 Observing Indexes:All Patients received examinations of blood,urine,feces,liver function (AST,ALT) and kidney function (Cre,BUN), recorded Symptoms of angina pectoris such as times for Painful onset etc,severity of pain duration ,along with relevant symptoms and signs such as TCM syndromes,tongue,pulse,heart rate,heartbeat rhythm,blood Pressure and ECG etc.4 Statistical Analysis:SPSS Statistics 17.0 software was used. For measurement data,t-test,paired t-test,rank sum test,Wilcoxon rank sum test and median test were applied: and for enumeration data,Chi-square test,Fisher's Exact Test: and the rank data were analyzed with Ridit analysis.Results: 1 Therapeutic effect for angina pectoris: for symptoms of AP in Treatment Group,obvious effective rate was28.6%,total improvement rate was 77.1%;for Control Group, respectively 25.7%and 77.4%;and the two groups were statistically no difference (P>0.05),Both groups can lower AP score and reduce the AP onset,and obvious differences were demonstrated when comparisons were made before and after treatment for each group (P<0.05), whereas no significant differences between the two groups (P>0.05),which indicated an equivalent effectiveness between the two groups on treating AP, lowering AP score and reducing AP onset frequency2 Efficacy on ECG; In Treatment Group,the obvious effective rate was 20% total improvement rate was 54.3%;for Control Group,respectively 14.3% and 51.4%;and no differences were statistically observed between the two groups (P>0.05).Both groups can decrease the total reduction of ST segment in every leads,and obvious differences were demonstrated when comparisons were made before and after treatment for each group (P<0.05),whereas no significant differences between the two groups (P>0.05),which indicated an equivalent effectiveness between the two groups on improving ECG.3 Efficiency on TCM syndromes: In Treatment Group,the total obvious effective rate was 31.4%,total improvement rate was94.3%:for Control Group, respectively 22.8% and 88.6%,no significant differences were observed between the two groups (P>0.05).Both groups can decrease the total score of TCM syndromes, and obvious differences were demonstrated when comparisons were made before and after treatment for each group (P<0.05),whereas no significant differences between the two groups (P>0.05),which indicated an equivalent effectiveness between the two groups on improving TCM syndromes and lowering total score of TCM syndromes.4 Analysis on Safety: :No untoward reactions and abnormalities were observed both in clinical observations and laboratory examinations.Conclusion:Astragalus Membranaceus Total Saponins Sodium Chloride Injection has been proved efficient through intravenous application in treating Coronary Heart Disease Angina Pectoris with TCM syndromes of Qi deficiency and blood stagnation,along with no statistical differences observed in comparisons on main indexes with that of Control Group. .Indexes of safety manifested no abnormality.