The Influence Of Lactoferrin On Hemoglobin And Iron Metabolism In Women's Middle Distance Runner

Objects: This experiment focuses on female middle-distance race athletes in Inner Mongolia Municipality. It aims to observe the changes of Hemoglobin, Iron metabolism and other relevant indexes to those athletes, which are influenced by Lactoferrin. In this experiment, the methodology is Double-blind,meanwhile, taking Lactoferrin or placebo and combining physical exercises.Materials and Methods: the experiment adopts double-blind method,dividing 14 runners into two groups randomly they are exercise group(7 persons),exercise plus nutrition group(7 persons) and dividing 12 students into two groups randomly too ,they are rest control group(6 persons),rest plus nutrition group(6 persons).Every person takes Nutrinatal (main ingredient is Lactoferrin) or placebo 2 pills. The experiment lasts 5 weeks, 6 days per week (except Sunday) to exercise group and 4 to 6 hours per day. All experimented in this group have generally same exercises. During this period, participants do not take other nutritional products besides daily diet and Nutrinatal or placebo. Blood in vein is let on Monday morning at the 0,2nd, 4th and 5th week, 4 times in total. Tested indexes include erythrocyte indexes (Hemoglobin, red blood cell count and Hematpcrit), Serum Iron, Serum Ferritin, Serum Transferrin and Serum Transferrin Receptor.Results:1. Comparing to rest control group, rest plus nutrition group's erythrocyte indexes increased, while they dropped significantly in exercise group. For exercise plus nutrition group, though the levels of erythrocyte indexes were lower than rest control group, they showed obvious trend of climbing up.2. Serum Iron levels of rest plus nutrition and exercise plus nutrition group went up, comparing with rest control group,while fluctuating downwards for exercise group. In addition, exercise plus nutrition group's number was higher than exercise group.3. The changes of Serum Ferritin in four different groups showed the consistency of variation. Especially in exercise plus nutrition group,it had clear increase from the 2nd to 4th week with statistics significance (P< 0.05).4. Serum Transferrin data was apparently distinct among groups at the 2nd week. It was the lowest to the rest plus nutrition group, in particular (P < 0.01) much lower than the exercise plus nutrition group. At the same time, the number from exercise group and exercise plus nutrition group had great differences as well (P<0.05). With the results of internal comparison in every group, it was obvious that the data to exercise group in the 2nd week rose quickly (P < 0.01).5. The level of Serum Transferrin Receptor of the rest plus nutrition group at the 4th week was evidently (P < 0.01) lower than those of others, and the group of exercise at the 4th week showed the highest level, much higher than the rest plus nutrition (P < 0.01) and exercise plus nutrition group (P < 0.05) respectively.Conclusions:1. We found that after 5 weeks Lactoferrin intake, athlete's erythrocyte indexes significantly increased. Therefore, Lactoferrin can be helpful to the index.2. Serum Iron level of exercise plus nutrition group is higher than that of exercise group after taking Lactoferrin for 5 weeks, so Lactoferrin may can offset Serum Iron drop caused by physical exercises.3. Serum Transferrin rose clearly, since exercise group has exercised for 2 weeks. In the mean time, it was lower, after taking Lactoferrin, than its corresponding control group. Thus, Lactoferrin may restrain the rise of Serum Transferrin caused by physical exercises.4. As the result of 5 weeks'exercises, Serum Transferrin Receptor increased rapidly, however, Lactoferrin supply brought it down significantly in rest group. Thus, Lactoferrin may relieve the rise of Serum Transferrin Receptor caused by physical exercises.