Studies On The Catalytic Asymmetric Addition Of Aldehydes And 1,4-Addition Of Dialkyl Phosphate To Enones

In this thesis,1,4-Addition of dialkyl phosphate to Enones and the asymmetric methylation reaction of aldehydes were studied in the presence of a chiral aza-semi-crown-ether azetidino alcohol ligands.1. The application of chiral azetidino alcohol ligand in the catalytic asymmetric 1,4-addition of dialkyl phosphite to enones. The chiral ligand 1 was used as catalyst to promote the asymmetric 1,4-addition of dialkyl phosphite to enones affording the corresponding products in up to 99% enantiomeric excess and in up to 99% excellent yields.2. The application of chiral azetidino alcohol ligand in the catalytic asymmetric addition of dimethylzinc to aldehydes. To test the chiral ligand catalytic efficiency and asymmetric induction effect, the application of chiral ligands in asymmetric methylation reaction of aldehydes, the experiments show that a catalytic amount of chiral ligand 1 can effectively catalyze the methylation reaction of the different types of aromatic aldehydes, the best results were achieved with 99% chemical yield and 99% ee.