Study On Room-Temperature Suzuki Reaction In Water Catalyzed By Palladacycle And The Related Mechanism

In this thesis, cyclopalladated 2-ferrocenylpridine and 2-phenylpridine were prepared. The catalytic activities of cyclopalladated 2-ferrocenylpridine were evaluated in the Suzuki reactions in water at room temperature. The related reaction mechanisms were also studied. The detail research is as follows:Cyclopalladated 2-ferrocenylpridine complex was synthesized and applied in the Suzuki cross-coupling reaction of aryl halides with phenyl boronic acid. It was found that the moderate to excellent yields were obtained in the presence of 0.5 mol% catalyst at the room temperature with K2CO3 as base, H2O as solvent.Cyclopalladated 2-phenylpridine complex was synthesized from 13C marked benzene. The mechanism of Suzuki reaction promoted by palladacycles was also studied by in situ 13C NMR spectra. The results suggested that Suzuki reaction catalyzed by cyclopalladated 2-ferrocenylpridine complex proceeded through a Pd(Ⅱ)/Pd(Ⅳ) catalytic cycle.