Synthesis And Properties Research Of Poly (Ethylene Glycol)-b-dendritic Poly (Aspartic Acid)s

First of all, Boc-Asp-COOH and ASP-COOC2H5 was synthesized by using natural L-aspartic acid. Then, G2.0 and G3.0 dendritic Poly(aspartic acid)s ethylester were obtained through liquid-phase synthesis method. MPEG-COOH (Mn=5000) and G3.0 dendritic Poly(aspartic acid)s ethylester dehydrated to get G3.0 MPEG-dendritic Poly(aspartic acid)s ethylester which would be hydrolysised and acidified. G3.0 MPEG-dendritic Poly(aspartic acid)s reacted with G2.0 and G3.0 dendritic Poly(aspartic acid)s ethylester separately and given to the target polymers G5.0 and G6.0 MPEG-dendritic Poly(aspartic acid)s ethylester. The polymers were characterized by1H-NMR, GPC, FT-IR and DSC. Compared with the solubility of polymers with different generation, CMC were measured and the micelles self-assembled by G5.0 and G6.0 MPEG-dendritic Poly(aspartic acid)s ethylester were studied on stability and distribution of particle size by means of1-NMR, DLS and SEM detection. MTX was uploaded by MPEG-dendritic Poly(aspartic acid)s ethylester micelles and the structure, physicochemical properties and drug release behavior were studied, in order to improve drug efficacy and reduced toxicity, for the purpose of developing new polymer micelle drug carrier systems.