Processing Study Of N-(tert-Butoxycarbonyl)-2-trifluoromethyl-4-piperidone

N-Boc-2- Trifluoromethyl-4-piperidone was chosen as the target substance in our study. The synthetic route of N-Boc-2- Trifluoromethyl-4-piperidone has been systematically investigated, and optimized this route, obtained very good yield. it is reasonable route4-piperidone has been widely used in the production of pesticides, medicines, finechemicals due to their pharmaceutical importance. This synthesis started from 4,4-dimethoxybutan-2-one, formed 4-methoxybut-3-en-2-one, thru this intermediate obtained 2-(trifluoromethyl)pyridin-4-o1, deoxidized by different reducing agent get-ed 2-(trifluoromethyl)piperidin-4-o1, this substance oxidation by different oxidants getting 2-(trifluoromethyl)piperidin-4-one, finally using Boc-protecting group protected nitrogen. In this process using ethyl 2,2,2-trifluoroacetate as the source of the trifluoromethyl. We focus on deoxidization, oxidation and finally step, obtained very good yield.In this paper, ethyl trifluoroacetate is used as a trifluoromethylation reagent containing building blocks, many menthods for the synthesis of trifuoromethyl containing heterocycles were studied. The mani part of this thesis:A new line has been fined to form 4-piperidone.We first synthesized N-Boc-2- Trifluoromethyl-4-piperidone, this line is easy to operate and adapt to manufacture and the reaction yield in creased. This process is a rather ideal of the kind of chemical compound containing three Fluorine. This work got the best of the synthesis.