Study On Ultra-high Pressure Levigating Jet Technology On Mineral Drug And Characterization Of The Powder

Choose Pearls, Realgar, Ocher, Talc, Cinnabar, Natural Copper, Keel, Dragon Teeth this 8 kinds of mineral drugs as deputation, smash them by powderful impact force and strong shear force of ultra-high pressure jet, and strong expansion force generated by high pressure relief in a moment, discuss the impact of pressure, dose size, smashing times on the smash, optimized optimum conditions of fine powder on preparation of mineral drugs; comparing the particle size, specific surface, particle size distribution, aerated density, liquidity, hygroscopic, chemical composition of ultra-high pressure jet powder, levigating powder and normal powder, and study dispersion stability of ultra-high pressure jet powder to find the best condition to keep the dispersion continue stable. In addition, put Realgar's ultra-high pressure jet powder as a representative to compare the in vitro antibacterial effect and toxicity, reveal the characteristics of mineral drug's ultra-high pressure jet powder, and provide a theoretical basis for mineral drugs smashing processing and application.Experimental results are as follows:[1] use the powder passed from 80 mesh screen to smash 3 times under 300MPa pressure, then we get the ultra-high pressure jet powder which average particle size less than 10μm and up to the general requirements of the ultra-fine powder; [2] compare to other powders:the ultra-high pressure jet powder (jet powder)'s average particle size reduced significantly while the specific surface increased obviously, particle size distribution width reduced, aerated density reduced, porosity increased, angle of repose increased, fluidity worse, moisture absorption percentage increased, relative critical humidity reduced, and at the same time the main chemical components remained unchanged; [3] the critical dispersion concentration of CMC-Na: Pearls,Dragon Teeth. Natural Copper 4.0wt%, Realgar 3.2wt%, Ocher 2.4 wt%, Talc Cinnabar 1.6wt%, Keel 6.0 wt%; the critical dispersion concentration of SLS to Ocher and Talc:Ocher 2.4wt%, Talc 3.2wt%; the critical dispersion concentration of SDS to Talc is 3.2wt%; the critical dispersion concentration of Tween-80 to Pearls and Cinnabar: Pearls4.0wt%, Cinnabar 0.8wt%. [4] comparison of Realgar's toxicity:The Realgar's LD50 of the jet powder in mouse is 2.5570±0.3110; The LD50 of the levigating powder in mouse is 5.9226±0.7795; The LD50 of the normal powder in mouse is 6.8935±0.9453, the results show that the Realgar's LD50 reduced and its toxicity was enhanced after being made into ultra-high pressure jet powder. [5] comparison of Realgar's efficacy:①he minimum inhibitory concentration (MIC) of E.coli.Bacteriostatic:the MIC of normal powder is 80g/L, levigating powder is 40g/L, jet powder is 20g/L;②the MIC of S.aureus: the MIC of normal powder is 10g/L, levigating powder is 5g/L, ultra-high pressure jet powder is 5g/L, the MIC of S.aureus and E.coli.Bacteriostatic of Realgar's ultra-high pressure jet powder is less than those of levigating powder and normal powder, it shows that the antibacterial effect of Realgar's ultra-high pressure jet powder is better than those of the levigating powder and the normal powder.In conclusion, the characteristics of ultra-high pressure jet powder smashed by ultra-high pressure levigating jet technology have changed obviously, the decrease of the particle size and increase of the specific surface improved drugs'efficacy, it has a positive significance on reduce of the clinical use of drugs and the reform of mineral powder system agents; at the same time, the main chemical components remained unchanged, this is good for keeping the drugs'original herbs, and have great significance on promoting the application of ultra-high pressure jet technology in the field of mineral drugs'smashing.