The Synthesis Of Cucurbit[n] Uril And The Interaction Between Cucurbit[n] Uril And Surfactant CTAB

Cucurbir[n]uril (CB[n]) family, as a new type of macrocycle host molecules, has attracted considerable attentions. Cucurbit[n]uril is one macrocycle cavitand compound with two portals, and it can recognized guests including metal ions and organic molecules via supramolecular interactions because of its unique cavity structure. It has great oppontunity to apply in the molecular self-assembly, catalysis, molecular recognition, medicine, pollution water treatment, mimic enzyme and drug pilot carrier.IR,Nuclear Magnetic Resonance(NMR),surface tension,conductivity and Thermogravimetric(TGA) Analysis have been carried out for the interaction between cucurbit[n]uril and surfactant. The research to help people to in-depth understanding and knowledge of the interaction and recogntion between of host molecule and guest molecule. As a part of the project sponsored by the national natural science funds (20703023), this paper is divided into six chapters:Chapter 1:The recent research progress of cucurbit[n]uril and their derivatives including structure, and properties was reviewed.Chapter 2:By acid catalysis method to synthesize glycoluril. The effect of different reaction condition on yield of glycoluril were analyzed, including moleratio of reactants, reaction time, pH.Chapter 3:Cucurbit[n]uril(n=5,6,7) was synthesized. Purified process and structures of the products were determined.Chapter 4:Surface tension, NMR and Thermogravimetric Analysis(TGA) have been carried out for investing the micellization behavior of cucurbit[6]uril (CB[6]) and cetyltriethylammonium bromide(CTAB) in NaCl aqueous solution. The apparent critical micelle concentrations, the stoichoimetry and the equilibrium constants for the inclusion compounds of CTAB with CB[6] have been determined. The influence of CB[6] and its complex on the micellization process of CTAB is analyzed. The results indicate that the addition of CB[6] inflicted pronounced impact upon micellization of CTAB, retarding the formation of CTAB micelles; in addition, CB[6] was found to form inclusion compounds with CTAB with the stoichoimetry of 1:1 and the equilibrium constants of 2.8×103L/mol.1HNMR spectroscopy and Thermogravimetric Analysis study further evidenced the inclusion behavior and the increase of the thermal stability of CTAB due to the host-guest complexation.Chapter 5:Surface tension and conductivity have been carried out for investing the micellization behavior of cucurbit[n]uril (n=5,7) and cetyl triethyl ammonium bromide(CTAB) in aqueous solution. The results indicate that the addition of CB[n] inflicted pronounced impact upon micellization of CTAB, retarding the formation of CTAB micelles.It shows that the constant envelope between surfactant molecules (CTAB) and CB[n] decreases with the increase of cucurbit[n]uril cavity. At the same time, with the smaller cavity of CB[n], the inclusion complexes is relatively more stable and more suitable for enveloping CTAB.Chapter 6:Conclusion and prospect.