Preparation Of A Novel Nano Drug Delivery Materials And Its Glucose-Sensitive Properties

Glucose-sensitive polymers were concerned because of their response to glucose and insulin release which are two potential applications. Phenylboric acid and phenylboric acid derivatives are a kind of glucose responsive materials. Phenylboric acid can complex witth hydroxyl compound, therefore we could use identification function of hydroxyl as dosing system of self-discipline or adjusting some life activities. Poly (ethylene glycol) (PEG) was chosen for this experiment materials with its nonpoisonous, without excitant, with good water-soluble and with good compatibility to many organic components, but also as a kind of ideal hydrophilic segment was widely used. This thesis synthesis amphiphilic polymer with glucose responsive which was maked up hydrophilic segment with MPEG and hydrophobic fragment with PPBDEMA. This key work are as follows:1,1,1,1-three hydroxyl methyl propane and phenylboronic acid as raw materials, we successfully decorate with propylene carbonyl chlorides, and synthesis of a new type of monomer PBDEMA. And then synthetic macromolecular initiator to get amphiphilic polymers which is MPEG- block PPBDEMA by ATRP polymerization; 2,We using solvent evaporation method to self-assembly, and get the nanoparticles system characterization of the nanoparticles morphology, diameter distribution and size and the ability of forming the micelle by TEM, DLS and CMC. Results show that the nano micro spheres formed in particle size distribution within roughly 100 nm, and its CMC scope is 49～115 mg/L;3,Using Nile Red and FITC-insulin as a kind of fluorescent molecular model drugs, and amphiphilic polymers MPEG-block-PPBDEMA as drug carrier, we carries on the test of its sugar response release behavior. The results showed that they can occur release behavior with sugar in the physiological conditions (37℃, pH 7.4), and they are more sensitivity to fructose response than glucose. Moreover, we further study its sugar response release behavior by the IR which show the structure changed and DLS approach which show particle size from 30 nm to 170 nm.