Study On Interface Properties Of Synthesized Glycolipids And Their Mixed Membranes With DPPE

The difference between the conformation of glycolipid molecules determine their diversifying bio-functional. Study on the interface properties of the synthesized glycolipid will play a part in the development of their potential application.In this paper, we use LB technology, atomic force microscope and the contact angle meter to study the interface properties of a series of novel synthesized glycolipids. In addition, glycolipids with different chain length or sugar ring are inserted into lipid LB monolayer and liposomal membrane with various ratios. The effect of the lipids mixing ratio and chain length of glycolipids on the stability and the permeability of these membranes are explored and discussed.The results show that 1-or 6-triazologluco-and galacto-lipid have differentiation in their surface pressure-molecular area (π-A) isotherms, implying that these structural and configurational diversity result in different arranging manner at air/water interface, 6-triazologlucolipid derivatives could increase the stability of PDA monolayer. When glycolipid with different chain length arrange at air/water surface, they stand at an angle and give different influencs on the properties of the DPPE/Gly monolayer. The density of the monolayer increases with the chain length of the glycolipids. The lipid mobility and transition temperature of DPPE/Gly liposomes are also influenced in different degrees. The results show that the longer the chain length of glycolipids, the higher the transition temperature and the better the thermal stability are obtained. However, the lipid mobility in bilayer membrane decreased. The content of the glycolipids also decrease the transition temperature of liposomes, implying that the thermal stability reduced. Furthermore, the correlations of thermal stability of liposome membrane with the density and intermolecular force of the LB monolayer are discussed.