The Preparation Of Copolymers Of Alginate And Diacetone Acrylamide And Their Applications In Drug Controlled Release

Alginate(SA) is a kind of natural polymer materials and it is obtained from brown algae. SA can react with polyvalent cations to form gels under mild conditions. These advantageous features have enabled SA to play an important role in biology, medicine, chemical engineering and drug-control-and-release. Diacetone acrylamide (DAAM), which is usually called diamine for short and has non-toxicity, can copolymerized with other compounds, degrade into intermediate product and can function as an extremely good bio-material. The work in this thesis used SA and DAA as raw material, and including content:Although SA has many advantages as the above mentioned, its strong hydrophilicity can easily make the drug release suddenly. In this work, DAAM-SA block copolymer was synthesized via graft polymerization of DAAM and SA through chemical synthesis and ultrasonic polymerization. These two methods can enhance the hydrophobicity. Then purification and characterization process were conducted on the as-synthesized products, Including the structure of the polymers, CMC in water and TGA.Loading and release behavior of model drug buprofen can prove that the hydrophobicity of the product was enhanced, the drug load capacity was improved and the products had better release-control capacityIn order to enhance the SA's drug load-and-release-controlling capacity, the work used SA and DAAM to form inter-penetrated hydrogel network. SA was hydrophobically modified. The swelling degree of the gel was measured.The loading and release behavior of model drug buprofen was also conducted. The results showed that inter-penetrated hydrogel network has exhibited better capacity in imbedding and release-controlling of the hrdrophobic drug.