Studies On Synthesis And Antifungal Activities Of Analogues Based On Aurone

In the prosess of developping efficient and less residue pesticide, plant-basedpesticides draw more and more attention for its extensive source, obtainning easily, safty tohuman and animals, environment friendly,and other advantages. In this study, we designedand synthesized23aurone analogues from sesamol through Friedel-Crafts reaction,α-bromination,cyclization and aldol condensation. All the synthesized compounds werecharacterized by IR,1H NMR and MS.The preliminary antifungal activity of the23compounds were tested by growth ratemethod to Fusarium graminearum,Fusarium oxysporum vasinfectum,Magnaporthegrisea,Botrytis cinerea,Curvulavia lunata,Valsa mali,Fusarium solani the antifungal activityresults showed that all compounds have differerntly inhibition on plant pathogenic funfusmycelial growth at concentration of100mg/L. Compound a-1,a-2,a-3,a-4,a-21,a-22and a-23showed a higher inhibition ratio to the Botrytis cirerea and the inhibition ratio is upto100%;Compound a-8showed better antifungal activity to Fusarium graminearum,Curvulavia lunata,Fusarium oxysporum vasinfectum and Magnaporthe grisea, the inhibitionratio were80.09%,92.50%,100%,94.87%respectively;The inhibition ratio of compounda-19to Fusarium solani and Curvulavia lunata were higher than azoxystrobin andthiabendazole,the inhibition ratio up to83.75and100%respectively.Other compounds havelower inhibition ratio, which were ranged from0%-60%.