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Study On The Pharmacokinetics Of Florfenicol,Enrofloxacin & Tilmicosin Microcapsules In Pigs

Posted on:2012-08-30Degree:MasterType:Thesis
Country:ChinaCandidate:Y N HuFull Text:PDF
GTID:2213330344951120Subject:Basic veterinary science
Abstract/Summary:PDF Full Text Request
The purpose of this study was to get the pharmacokinetic parameters of the new dosage forms of florfenicol, enrofloxacin, and tilmicosin, after a single oral administration in pigs. Compared with their original powder, then provided theoretical basis for rational drug use.1. Pharmacokinetic parameters of Florfenicol Microcapsules (FM) and Florfenicol in 6 pigs were calculated.Pigs were treated with a single dosage of FF (30 mg·kg-1) orally, while the blood samples were collected from precaval vein within 36 hour after giving drug. The concentrations of FF in serum were determined by high performance liquid chromatography (HPLC). The result showed that the one-compartment open modle with first-order absorption factor adequately describes concentrations of FM and FF in serum disposition and best concentration-time equations are: CFM=3.772 7 (e﹣0.047t-e﹣0.8477t), CFF=0.375 9(e-0.258 1t-e-4.670 9t). The primary pharmacokinetic parameters of FM and FF are: t1/2Ka=(0.944 6±0.507 5) h and (0.155 0±0.030 1) h, t1/2Ke=(15.214 0±3.024 9) h and (2.694 5±0.169 5) h, AUC=(77.311 1±13.312 7) mg·L-1·h and(1.374 7±0.606 0) mg·L-1·h, Cmax=(2.937 1±0.232 2) mg·L-1 and (0.298 3±0.023 9) mg·L-1·h, Tmax=(3.951 0±1.533 9) h and (0.675 3±0.104 6) h. It will be seen that Florfenicol microcapsules was completely absorbed with a slowly absorption rate, and which was eliminated slowly in the blood after single oral administration.2. Pharmacokinetic parameters of Enrofloxacin Microcapsules(EM) and Enrofloxacin (ENR) in 6 pigs were calculated.Pigs were treated with a single dosage of ENR (30 mg·kg-1) orally, while the blood samples were collected from precaval vein within 72 hour after giving drug. The concentrations of ENR in serum were determined by HPLC. The result showed that the two-compartment open modle with first-order absorption factor adequately describes concentrations of EM and ENR in serum disposition and best concentration-time equations are: CEM=11.326 3e-0.353 8t+5.420 6e-0.066 1t-16.746 9e-0.979 8t, CENR=11.251 1e-0.934 7t+5.330 1e-0.079 9t-16.581 2e-2.965 7t. The primary pharmacokinetic parameters of EM are: t1/2ka=(0.769 5±0.250 9) h; t1/2a=(2.160 3±0.704 1) h; t1/2β=(10.522 4±0.719 5) h; AUC=(92.924 3±5.308 4) mg·L-1·h. It will be seen that EM was completely absorbed with a slowly absorption rate, and which was eliminated slowly in the blood after single oral administration.3. Pharmacokinetic parameters of Tilmicosin Microcapsules(TM) and Tilmicosin (TMS) in 6 pigs were calculated.Pigs were treated with a single dosage of TMS (30 mg·kg-1) orally ,while the blood samples were collected from precaval vein within 72 hour after giving drug. The concentrations of TMS in serum were determined by HPLC. The result showed that the two-compartment open modle with first-order absorption factor adequately describes concentrations of TM and TMS in serum disposition and best concentration-time equations are: CTM =5.927 7e-0.444 8t+2.641 7e-0.051 0t-8.579 4e-2.471 4t, C TMS =5.083e-1.233 0t+2.366 4e-0.086 4t-7.449 4e-6.585 7t The primary pharmacokinetic parameters of tilmicosin microcapsules are: t1/2ka=(0.291±0.057) h; t1/2a=(1.954±0.267) h; t1/2β=(13.602±0.611) h; AUC=(61.344±3.371) mg·L-1·h. It will be seen that tilmicosin microcapsules was completely absorbed with a slowly absorption rate, and which was eliminated slowly in the blood after single oral administration.
Keywords/Search Tags:Florfenicol, Enrofloxacin, Tilmicosin, Microcapsules, Pharmacokinetics, Pigs
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