Comparison Between Sufentanil And Fentanylon Their Clinical Effect In Neurosury

Objective:Comparing the clinical effects of sufentanil with fentanyl in neurosurgery anesthesia.Methods:50 adult patients were randomly divided into sufentanil (n=28) and fentanyl group (n=22). There were no difference in ages, gender, body weight and NYHA cardiac function (all p>0.05) between the two groups. They had comparable. 5min after induction of anesthesia,0.2μg/kg/h of sufentanil (sufentanil group) and 2μg/kg/h of fentanyl (fentanyl group) were continuously pumped. Hemodynamic parameters pre or postanesthesia, recovery time, other drugs usage adverse events, VAS scores postoperatively, and blood sugar, concentration of epinephrine in the plasma were compared between the two groups.Results:The general information and operation characteristics of both group had no significant difference (p>0.05). Patients in both groups MAP, HR, SVRI levels post-anesthesia were significantly lower than that of pre-anesthesia, (p<0.05). But no significant difference found between the groups (p>0.05). After intubation, head-holder fixed and closed the dura, patients in sufentainil group MAP, HR, SVR were significantly lower than that of in fentanyl group (p<0.05). The Patient's recovery time from anesthesia, spontaneous breathing regaining, time of tracheal extubated were much shorter in sufentanil group than that of in fentanyl one (all p<0.05). Incidence of shivering, agitation postoperatively and PONV in sufentanil group were significantly lower than that of in the fentanyl group (p<0.05). there were no significant differences in other adverse events and usage of other drugs between two groups (p>0.05). Postoperative VAS score immediately post-extubation,2h after the operation were significantly lower in sufentanil group than that of in fentanyl group (p<0.05). Still VAS score 48h after surgery was no significant difference between two groups (p>0.05). There was no intraoperative awareness found between two groups followed up. There were no significant differences in both the amount of blood sugar and concentration of epinephrine in the plasma at pre-anesthesia, after skin incision,30min post-anesthesia, immediate post-extubation between two groups (p>0.05).Conclusion:Sufentanil has stronger and longer duration of analgesia than that of fentanyl. it can effectively inhibit the circulative response to tracheal intubation and hemodynamic are stable during tracheal extubation. Recovery rapidly from anesthesia, little respiratory depression, lower incidence of shivering, agitation, and other adverse events post-operations to compare with fentanyl, there were much superiority in neurosurgery anesthesia.