Variation And Significance Of Serum CARP,hs-CRP In Patients With Atrial Fibrillation

Objective:To investigate the changes and significance of serum levels of CARP,hs-CRP in patients with atrial fibrillation, and evaluate the relationship among CARP,hs-CRP and cardiac infunction.Methods:A total of 124 patients with hypertension or coronary heart disease were enrolled in this study,including atrial fibrillation group (n=64) and sinusrhythm group (n=60).The two groups were divided into three subgroups(the NYHA classⅠ,the NYHA classⅡand the NYHA classⅢ) according to the NYHA cardiac function class.Serum CARP levels in all patients were measured by enzyme-linked immunosorbent assay (ELISA),and serum hs-CRP levels were measured by latex enhance immune and turbidimetric immunoassay(PETIA).Then the levels of them were dealed with statistical analysis.Results:1.The levels of serum CARP,hs-CRP in atrial fibrillation group were significantly higher than those in sinus rhythm group(P<0.05).In the same NYHA class subgroup, the levels of serum CARP,hs-CRP in atrial fibrillation group were significantly higher than those in sinus rhythm group(P<0.05)。2.The levels of serum CARP,hs-CRP both in atrial fibrillation group and in sinus rhythm group were in sequence increased significantly with the NYHA class(P<0.05).Conclusion:1.The levels of serum CARP,hs-CRP in atrial fibrillation group were significantly higher than those in sinus rhythm group.The levels of serum CARP and hs-CRP were significantly increased with the deterioration of cardiac function.2.CARP and hsCRP may be involved in the occurrence and sustainment of atrial fibrillation.The levels of serum CARP,hs-CRP may serve as an independent index of atrial fibrillation.