| Background and objectives Subclinical hypothyroidism is highly prevalent in the general population, especially in the elderly. There is a clear relation between subclinical hypothyroidism and cardiovascular events in patients with chronic kidney disease (CKD). However, the prevalence of subclinical hypothyroidism in persons with CKD non-dialysis is not well defined. We conducted a cross-sectional study to analyze the prevalence of subclinical hypothyroidism in persons with CKD non-dialysis on different renal function.Methods In this study,1158 adult inpatients with CKD non-dialysis were consecutively enrolled.We collected their demography index, clinical and laboratory data. Glomerular filtration rate (GFR) was estimated by the abbreviated Modification of Diet in Renal Disease equation applied in Chinese. After excluding 142 participants with abnormal serum FT,, concentrations,1016 subjects were analyzed. Multivariable logistic regression was used to evaluate the independent association between prevalent subclinical hypothyroidism and estimated GFR with SPSS13.0 soft ware.Results Among 1016 adult subjects,190 (18.70%) had subclinical hypothyroidism. The prevalence of subclinical hypothyroidism increased from 11.14% at an estimated GFR≥60 ml/min per 1.73 m2 to 30.24% at an estimated GFR<15 ml/min per 1.73 m2 (P＜0.05). The patients with lower estimated GFR had an increased odds of subclinical hypothyroidism after adjusting for gender, age, fasting plasma glucose, total cholesterol, triglyceride concentrations (OR=1.311; 95% CI:1.207～1.415). In multivariable logistic regression analyses, the prevalence of subclinical hypothyroidism is inverse correlation with estimated GFR (r=-0.351, P=0.000)Conclusions These findings suggest that the prevalence of subclinical hypothyroidism is high among persons with CKD non-dialysis, and eGFR is independent predictor of subclinical hypothyroidism in patients with chronic kidney disease. |
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