The Effect Of Telmisartan And Amlodipine Besylate On Blood Pressure And Blood Pressure Changeability In Elderly Patients With Hypertension

ObjectiveThe primary hypertension is one of most common cardiovascular diseases among the senior citizens. There is a growing tendency of its disease incidence year by year. Long-term hypertension will seriously threaten the senior citizens' health, finaly it may cause apoplexy, heart disease, kidney function failure and so on, which is the main reason that drops the life quality of the senior citizens and even causes the death. Therefore, besides the early prevention hypertension, it appears especially important that how to positively control the blood pressure of the old patients and properly choose the medicine. This clinical trial is designed to observe and analise the blood pressure change of old patients'blood pressure before and after taking the two kinds of medicine above, attempting to discover the influence of them. This will provide a new target for clinician to reasonably select the blood pressure medicine, also provide the new mentality and the basis for the control senile hypertension's treatment. Materials and MethodsHaving collected 103 examples of 1-2 level of old age patients with elevated blood pressure treated in out-patient department of our hospital from October,2008 to September,2009. All patients conformed to the middle and old aged hypertension's diagnosis standard in "the 2005 Chinese Hypertension To prevent and control Guide". Patients of group A orally took 80mg/d Telmisartan Tablets, while group B orally took the Amlodipine Besylate, and all of them were treated for 12 weeks. In experimental period, every week we diagnosed them one time regularly, mainly to observe the blood pressure, the heart rate and so on. Patients'dynamic blood pressure were monitored for 24 h before the treatment and after 12 weeks treatment, completely using portable unharmful dynamic blood pressure monitor to monitor dynamic blood pressure (BP) and blood pressure changeability (BPV). The data evaluation was handled with SPSS11.0 program and the data were expressed by mean±standard deviation. The difference of one group before and after treatment was analyzed with paired t-test. The assessment of differences between groups was analyzed with independent t-test.α=0.05 has statistics significance inspection standards as the difference.ResultsThere are 103 examples selected in all. The two groups' baseline target has the homogeneity.1. After treated, each group's blood pressure is lower than before the treatment, the difference has statistics significance (P<0.05).2. After treated, B group's nSBP and nDBP drops is more remarkable, the difference has statistics significance (P<0.05).3. Comparing the blood pressure changeability, the B's dSBPV and dDBPV number is bigger, the difference has statistics significance (P<0.05); After treatment, comparing nSBPV and nDBPV, we found the number of group A is bigger. The difference has statistics significance (P<0.05). ConclusionsThe Telmisartan Tablets and the Amlodipine Besylate can actively control the blood pressure of the elderly Patients with Hypertendion. Because the different between the two Pharmacology characteristics, they have different influence on the changeability of blood pressure...