TCM Syndrome Type Distribution Of Coronary Heart Disease In Fuzhou City And The Relationship With The Activity Of Platelet-activating Factor Receptor

Objective:To explore TCM syndrome distribution laws in patients with coronary heart disease(CHD) in Fuzhou city. To study on relationship between TCM syndrome Differentiation-Type of CHD and the activity of platelet-activating factor receptor,provide an objective basis for TCM Syndrome Differentiation-Type of CHD,and provide new ideas and methods for CHD prevention and treatment of combination of Chinese and Western medicine.Methods:1.507 patients with confirmed CHD from different area in Fuzhou city were diagnosed to different TCM syndrome by the standard of Syndrome Differentiation for coronary artery diseases revised in 1990, and carried out a clinical survey. The TCM syndrome distribution laws, the correlation of the TCM syndrome and complications, gender, age were analysed..2.282 hospitalized patients with confirmed CHD applied enzyme-linked immunosorbent method (ELISA) testing PAF-R activity level.Results:1. CHD main syndromes distribution in Fuzhou city:Classified according to deficiency or excess sydrome, blood stasis syndrome was the most popular syndrome in patients with CHD(63.12%), the second respectively was Qi deficiency syndrome (59.37%) and phlegm retention syndrome (45.56%). In the combined syndrome, qi deficiency plus blood stasis syndrome was the main syndrome (12.2%), the second respectively was qi deficiency plus blood stasis and phlegm retention syndrome (9.1%), and qi deficiency plus phlegm retention syndrome (8.1%). The distribution of various TCM syndrome in the different age groups had the significant difference (p<0.05), but the same result was not shown in the different gender(p>0.05).2. The change of PAF-R activity level and the relationship between PAF-R activity level and TCM Syndrome Differentiation-Type in CHD:The PAF-R activity level of CHD group (16.03±3.49ng/ml) was obviously higher than that of normal group (p<0.01); There were some siginificant results about PAF-R activity level in TCM-SDT of CHD. Whether Qi stagnation syndrome (13.61±3.33 ng/ml),blood stasis syndrome (16.23±3.22 ng/ml), phlegm retention syndrome (15.91±3.57ng/ml), cold condensation syndrome (19.85±2.61 ng/ml), blood stasis- phlegm retention syndrome (15.97±3.17 ng/ml), and blood stasis-Qi stagnation syndrome (13.66±2.89ng/ml) and blood stasis±cold condensation syndrome (21.48±1.32ng/ml),or qi deficiency syndrome (13.19±1.19ng/ml), yin deficiency syndrome (16.18±0.72 ng/ml), Yang deficiency syndrome (20.04±0.62 ng/ml),Qi+Yin Deficiency (18.16±0.45 ng/ml), Yin+Yang deficiency (22.12±0.71ng/ml),their PAF-R activity levels were significantly higher than the that of normal group (p<0.01). Cold coagulation syndrome in the empirical group was significantly higher than Qi stagnation syndrome, blood stasis+Qi stagnation syndrome,(p<0.01),and significantly higher than phlegm retention syndrome,blood stasis syndrome, blood stasis- phlegm retention syndrome (p<0.05). blood stasis+cold coagulation syndrome was significantly higher than Qi stagnation syndrome, blood stasis+Qi stagnation syndrome, phlegm retention syndrome,blood stasis syndrome, blood stasis- phlegm retention syndrome(p<0.01).Qi deficiency syndrome group was significantly lower than Yin deficiency syndrome group, Yang deficiency syndrome group, and Qi+Yin Deficiency group, Yin+Yang Deficiency syndrome group (p<0.01). Yin deficiency syndrome group was significantly lower than Yang deficiency syndrome group, and Qi+Yin Deficiency group,Yin+Yang Deficiency syndrome group (p<0.01). Qi+Yin Deficiency group was significantly lower than the Yang Deficiency syndrome group and Yin +Yang deficiency syndrome group (p<0.01). Yang Deficiency syndrome group was significantly lower than the Yin+Yang deficiency syndrome group (p<0.01).Conclusion:1. Blood stasis, qi deficncy and phlegm retention syndrome are the basic mechanism of CHD in Fuzhou city. The combined syndrome of the inclusion each other among Blood stasis, qi deficncy and phlegm retention syndrome is the main combination pattern. The combination of syndrome owns certain regularity.2. PAF-R activity level of patients with CHD was abnormal high, indicating that PAF-R activity in the clinical diagnosis of CHD provide reference value.3. PAF-R activity level of patients with CHD in TCM Syndrome Differentiation-Type were different. so it had reference value on TCM Syndrome Differentiation-Type of CHD.