The Study On Correlation Between TCM Syndrome Type Of Carotid Atherosclerosis And Matrix Metalloproteinase (MMPs), Tissue Inhibitors Of Metalloproteinase (TIMPs)

Objective:Through the clinical syndrome differentiation, observation of carotid atherosclerosis in patients with different TCM syndromes and serum matrix Metalloproteinases (MMPs), tissue inhibitor of matrix Metalloproteinases (TIMPs) relevance of content, provide a basis for the standardization of clinical syndromes of carotid atherosclerosis, assess various TCM syndrome types in patients with plaque stability and the risk of clinical events.Methord:According to the selection and exclusion criteria collection cases and collected four diagnostic methods of TCM information, summary of TCM. Collect patient age, sex, body mass index, smoking history, family history, risk factors and serum lipid, hypertension, diabetes and other common information, study on the relationship between TCM syndrome type and common risk factors. Detection of carotid artery in patients with porridge sclerosis lesions, collecting its lesion, patch size, nature, and ultrasonic sclerosis lesions classification and grading and scoring, Crouse of the carotid artery plaque integral calculation, study on the relationship between TCM syndrome type and its plaque lesions. Detection of serum levels of MMPs and TIMPs in patients, study on carotid atherosclerosis in patients with different TCM syndrome type and relationship between MMPs, TIMPs.Result:Through the study, found that age, sex, patient factors such as smoking, body mass index of carotid atherosclerosis TCM syndrome differentiations patients with less effect. A history of hypertension and diabetes history, and the significantly higher proportion of kidney essence> spleen deficiency and sputum resistance group> blood stasis group. Patients triglycerides (TG), total cholesterol significantly higher (TC), and kidney essence> spleen deficiency group> sputum resistance groups and blood stasis group, high-density lipoprotein (HDL), kidney essence is significantly lower deficiency group< spleen and sputum resistance group< blood stasis group. Different patients with TCM syndrome type distribution of carotid plaques position no obvious difference, bilateral Crouse integral, film thickness show blood stasis group, spleen and sputum resistance group, kidney essence is increasing gradually deficiency group, and spleen phlegm resistance group, kidney essence is obviously higher than deficiency group and blood stasis group. Qi stagnancy and blood stasis syndrome, spleen and kidney essence sputum resistance type deficiency type patients with carotid atherosclerosis MMPs, TIMPs level, serum MMPs/TIMPs value both rose and rose and blood stasis syndrome relatively small, spleen and kidney essence sputum resistance type deficiency type increased, the proportion of MMPs and TIMPs imbalance.Conelusion:A history of hypertension and diabetes who are predisposed to history of carotid porridge, and proportion of magnetic sclerosis kidney essence> spleen deficiency group> sputum resistance groups and blood stasis group. Patients triglycerides (TG), total cholesterol significantly higher (TC), and kidney essence> spleen deficiency group> sputum resistance groups and blood stasis group, high-density lipoprotein (in HDLC), kidney essence is significantly lower deficiency group< spleen and sputum resistance group< blood stasis group. Different patients with TCM syndrome type distribution of carotid plaques position no obvious difference, bilateral Crouse integral, film thickness show blood stasis group, spleen and sputum resistance group, kidney essence is increasing gradually deficiency group, and spleen phlegm resistance group, kidney essence is obviously higher than deficiency group and blood stasis group. Qi stagnancy and blood stasis syndrome, spleen and kidney essence sputum resistance type deficiency type patients with carotid atherosclerosis MMPs, TIMPs, serum MMPs/TIMPs value were increased significantly, spleen and kidney essence of sputum resistance increased obvious deficiency type, occurred between higher risk of clinical events, especially in the kidney essence of why deficiency. In the clinical work should pay attention to assess sputum resistance of pixu with kidney essence of deficiency type carotid atherosclerosis patients, especially the risk stratification of patients with kidney essence deficiency, attention should be paid to prevention of clinical cardiocerebrovascular events.