The Effect Of Inhaled Corticosteroids In The Treatment Of Acute Episode Of Bronchial Asthma In Older Adults

Background:Bronchial asthma is a common chronic airway inflammatory disease of respiratory system. Using inhaled corticosteroids is an effective treatment in these patients, it is necessary to investigate the relationship of dose-response of inhaled corticosteroids and whether it can replace oral corticosteroids.Objective: During the study, try to investigate the best method of treatment of acute exacerbation of bronchial asthma within different ways, different does of corticosteroids.Methods: 83 patients diagnosed acute exacerbation of bronchial asthma were divided into 4 groups in the randomized block method. There are 18 patients in the A group of BUD 2000ug, quantitative budesonide inhalation 500ug once, every 30 minutes, the total inhaled dose is 2000ug/d; 20 patients in the B group of BUD 4000ug, quantitative budesonide inhalation 1000ug once, every 30 minutes, the total inhaled dose is 4000ug/d; 22 patients in the C group of BUD 6000ug, quantitative budesonide inhalation 1500ug once, every 30 minutes, the total inhaled dose is 6000ug/d; 21 patients in the D group of prednisone, 30mg/d, take at a draught. Pulmonary function test, clinic assessment score and adrenocortex function test were completed at the beginning, the end and the course of the trial.Results: Within the 4 groups of patients with acute exacerbation of bronchial asthma, clinical assessment score were declined after the treatment, with statistical differences(P<0.05)The value of FEV₁ and PEF which reflect the function of tracts improved with statistical differences(P<0.05). There were similar improvements in clinical assessment score and lung function in the four groups at the time of 4 hours and the second day after treatment; 7 days after the beginning of treatment similar improvements in clinical assessment score and lung function in the four groups, and the difference of the improvements in lung function between the group of BUD6000ug and pred was not significant, but these lung function parameters were well improved in the group of BUD6000ug (C))> BUD4000ug (B)> BUD2000ug (A).The urocortisol test in 24 hours which reflects the adrenocortex function were declined in the four groups ,with no significant difference.Conclusion: Using ICS was an effective method in the treatment of acute exacerbations of bronchial asthma undoubtedly. When concerning the efficacy and side effects, inhaled corticosteroids was an ideal method in the treatment of acute exacerbations of bronchial asthma.