The Preliminary Clinical Study Of Ultrasound Elasticity Imaging Technology To Evaluate The Elasticity Changes Of The Deep Vein Thrombosis In Different Stages

To use real-time qualitative ultrasound elasticity imaging (UEI) technology to evaluate the elasticity changes of the deep vein thrombosis (DVT) in different stages.Methods49 patients with DVT confirmed by clinical symptoms and conventional ultrasound examination were enrolled in this study. The thrombosis was divided into acute, sub-acute, and chronic stage according to the onset of the symptoms. The ultrasound elastic image characteristics of the thrombosis were observed in different stages with HITACHI EUB-7500 and the thrombosis was evaluate by establishing 5 scores rating. the strain ratio between the muscle tissue around the thrombosed vein and the thrombosis was calculated.ResultsIn ultrasound elasticity image, the acute thrombosis was mainly red, the sub-acute thrombosis was green, and the chronic thrombosis was blue. The elasticity scores of the chronic thrombosis group was higher than the sub-acute thrombosis and the acute thrombosis group(P<0.01, P<0.001). The elasticity scores of the sub-acute thrombosis group was higher than that of the acute thrombosis group(P<0.001). The strain ratio of the chronic thrombosis group and the sub-acute thrombosis group were higher than that of the acute thrombosis group(P<0.001, P<0.05). The strain ratio of the chronic thrombosis group was higher than that of the sub-acute thrombosis group(P<0.05).ConclusionUltrasound elasticity imaging technology can be used to evaluate the hardness changes of deep venous thrombosis in different stages. The colour of Ultrasound elastography are different when the thrombosis in different stages. The strain ratio and the elasticity scores of thrombosis are significantly different when the thrombosis in different stages. Since the hardness of thrombosis relates to the amount of fibrin and collagen, the ultrasound elasticity evaluation of thrombosis can reflect the fragility of thrombosis (thrombosis fragmentation and loss) and the formation time of thrombosis. It has important clinical value and is worth further study. PART two Quantitative ultrasound elasticity imaging technology to evaluate the elasticity changes of the deep vein thrombosis in different stagesObjectiveTo explore the difference of Young's modulus in the deep vein thrombosis(DVT) at different stages.Methods67 patients with definite symptom and formative time DVT by conventional ultrasound diagnoses were enrolled in this study. The thrombosis was divided into acute, sub-acute, and chronic stage according to the onset of the symptoms. The Young's modulus of the deep vein thrombosis were measured in different stages with shear-wave elasto-sonography (AixPlorer model, Supersonic Imagine, Aixen Provence, France) .The differences of Young's modulus among different stages was analyzed.ResultsYoung's modulus of acute thrombosis was 6.37±2.15 kPa,Young's modulus of subacute thrombosis was 13.01±1.89 kPa and Young's modulus of chronic thrombosis was 26.51±6.23 kPa.The Young's modulus of chronic thrombosis were significantly higher than the acute and subacute thrombosis, it had statistically significan(tP<0.0001,P<0.001). The Young's modulus of subacute thrombosis were significantly higher than the acute thrombosis, it had statistically significant(P<0.001).There were no significant difference of the age and the sex among three groups(P>0.05). ConclusionShear wave elasticity imaging technique can quantitatively measure the absolute value of thrombotic hardness (fragility) and the Young's modulus difference in the acute, subacute and chronic thrombosis.Because the hardness of thrombus relates to the formation time and composition of thrombus,which is risk factors of thrombosis falling,it has important clinical promote value to quantitatively evaluate the thrombotic hardness.