The Clinical Analysis Of Cervical Intraepithelial Nepopla And Mecronvsive Carcion Fo Cervix

Background and ObjectiveCervical intraepithelial neoplasia (CIN) is a group of closely relatedprecancerous lesions to invasive cervical cancer. In recent years, it gives highrespect to the potential malignant of CIN. It is a hot epidemiologicalinvestigation to explore the factors affecting the development of CIN. And withthe application of various diagnostic methods and improvement, it makes the CINcan be early detected, early diagnosised and be early treated, thereby it isreducing the incidence of cervical cancer. However, there are still many problemsin standardization of diagnostic procedures and treatment of CIN, it is worthfurther exploration.Microinvasive carcinoma of cervix (MIC) is the phaseⅠa1 andⅠa2 of cervicalcancer.Ⅰa1 Cervical cancer is the depth of invasion less than 3mm, the widthof no more than 7mm of microscopic invasive cancer;Ⅰa2 Cervical cancer is thedepth of invasion in 3～5mm, the width of no more than 7mm of microscopic invasivecancer. There are more and more MIC. How to understand the concept of MIC, howto evaluate the colposcopic biopsy and cervical conization in the diagnosis ofMIC, and how to select subsequent treatment based on cone biopsy pathology arethe problems that the gynecologist have to face to.The subject is retrospectively analyzing 199 cases of cervical intraepithelialneoplasia and microinvasive carcinoma of cervix in our hospital, discussing thediagnosis and treatment of early cervical lesions, and to provide the basis ofCervical cancer and precancerous lesions of the standardized and individualizeddiagnosis and therapy.MethodsA retrospective study was carried out in the 199 cases with CIN/CIS/MIC between November 1995 and September 2010 in the Tumor Hospital of ShanTou UniversityMedical College of women's tumor section. SPSS Statistics 17.0 software was usedfor analyzing. Measurement data is using one-way ANOVA, count data using X2 test.Default test levelα=0.05.Resulesults1.The positive rate of cervical cytology is 89.43% (110/123). False negative rateis 10.57% (13/123).2. Diagnosis rate of Cervical cytology: LSIL 16.67% (3/18), HSIL 94.87% (37/39),the differences are statistically significant (P <0.05).3. There are totally 28 patients underwent HPV testing, 22 are positive, thepositive rate is 78.57%.4. The consistent rate of CIN/CIS/MIC of cervical conization based on colposcopicis 55.14%. The difference between conization and colposcopic cervical biopsy is24% (6/25). The difference was not statistically significant (P<0.05).5. The diagnostic accuracy rate about conization of cervical intraepithelialneoplasia is 96.25%, the cure rate is 16.25%, the residual lesions rate is 83.75%.The therapeutic effect of conization among the CIN/CIS/MIC is differentstatistically significant.Conclusions1．CIN is important to be early diagnosed and treated．2．The happening of CIN and the infection of HPV is closely connected,so theinfection of HPV before treatment should be paid more attention to．3．Cervical conization based on colposcopic is a simple, accurate and effectivemethod to screen and diagnosis for cervical lesions ,but it can not replaceconization. It is more appropriate to diagnosis the high-level cervicalintraepithelial neoplasia by cone biopsy .In the treatment of choice for high-level cervical intraepithelial neoplasia in patients with cone biopsy shouldbe the preferred treatment, then according to the requirements of patients withpathological results and other factors to determine further treatment andfollow-up program.