| 【Objective】: Dexmedetomidine is aα2 adrenoceptor agonist which has antisympathesis, sedation and analgesia effects but no respiratory depression. Several studies showed that dexmedetomidine could reduce the consumption of inhaled anesthetics in gynecology patient under general anesthesia. There was no available information of dexmedetomidine on gynecology patients under combined spinal epidural anesthesia. The current study was to investigate the sedative effects of dexmedetomidine supplement with profofol on gynecology patients under combined spinal epidural anesthesia.【Methods】:Double-blind, randomized controlled investigating methods were employed.80 gynecology patients were randomly divided into four groups (Group A, B, C and D):10ml of 0.9% NS or dexmedetomidine (0.5ug/kg, 1ug/kg,1.5ug/kg) were used i.v within 10min respectively by micro-pump after CSEA. And then propofol was used to maintain the BIS values at 55±5. All patients heart rate, SBP, DBP, breathing frequency, tidal volume, PETCO2, SPO2, BIS, the Ramsay sedation scale, the dosage of propofol and fentanyl at every 5min and the resuscitation time were recorded.【Results】:Intravenous injection 0.5ug/kg, 1ug/kg,1.5ug/kg of dexmedetomidine could reduce the consumption of propofol by 25%,34% and 44% on gynecology patients under combined spinal epidural anesthesia respectively. And ruduce the consumpion of fentanyl. The BP and heart rate were slightly decreased, but still within normal range when 0.5-lug/kg dexmedetomidine used. Obvious hypotension and bradycardia in some patients were found when 1.5ug/kg dexmedetomidine used. The respiratory function was not influenced obviously in all patients. All patients revived within 7-10min after the propofol was stopped and no other complications were found.【Conclusion】:Small doses of dexmedetomidine i.v supplement with propofol can decrease the propofol consumption and provide satisfied sedation on gynecology patients under combined spinal epidural anesthesia. |
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