The Significance Of RAD51 G135C Polymorphysm In Lung Cancer

Objective:To investigate the relationship between RAD51 G135C polymorphism, Jung cancer risk,pathological characteristic, and p53 mutation in lung cancer.Methods:A total of 80 lung cancer cases and 40 controls with lung non-neoplastic diseases were collected. We analyzed the genotypes of RAD51 (135GC) by PCR-RFLP and detected the p53 mutation of 80 lung cancer cases by imnunohistochemistry,then determined the association with the genotypes,lung cancer risk,pathological characteristic and p53 mutation in lung cancer.Results:(1)The frequency of G/G,G/C and C/C genotype was 83.7%,15.0% and 1.3% in cases and was 92.5%,7.5% and 0.0% in controls. When G/G served as the reference group, variant genotype (G/C and C/C) had a significant increased risk of lung cancer(P<0.05).(2) There were no significant difference between the genotype of RAD51 and the pathological type and grade(P>0.05). (3)There were no significant difference between the distribution frequency of the genotypes of RAD51 in different p53 mutation status in lung cancer(P>0.05).Conclusion:RAD51 G135C gene polymorphism may be a risk factor for lung cancer and the person who carry the variant genotype (G/C and C/C) had a significant increased risk of lung cancer.