Synthesis And Evaluation On Anticonvulsant And Antidepressant Activities Of 5-Alkoxy (Phenoxy)-tetrazolo [1,5-a] Quinazolines

In order to find more safe and effective new anti-epileptic drugs, a series of 5-alkoxy (phenoxy) tetrazolo[1,5-a]quinazoline derivatives was synthesized using 2,4-dichloroquinazoline as the starting material. Their anticonvulsant activities were evaluated by the maximal electroshock test (MES). Results demonstrated that most of the test compounds exhibited weak anticonvulsant activity. Taking into account that depression is often the complication of epilepsy, research also shows that epilepsy and depression may have a common pathogenesis, and while some drugs have been clinically used for the treatment of these two diseases. Therefore, the antidepressant activity of this series of compounds were also measured by forced swimming test in mice (FST). The results showed that most of the compounds had strong antidepressant activity. Two compounds, namely 5-(hexyloxy)tetrazolo[1,5-a]quinazoline and 5-(4-methoxyphenoxy)tetrazolo[1,5-a] quinazoline, showed significant antidepressant activity, which decreased the immobility time by 62.2% and 51.7% at 100 mg/kg dose level (i.p).