Effect Of Dexmedetomidine On Perioperative Cortisol And IL-2 In Serum In Cervical Cancer Patients

[Background] Anesthesia and surgery can reduce the immune system with low immunity in cervical cancer patients. Combined drug can reduce the dosa-ge and the side effects.Dexmedetomidine is a highly selective alpha-2 adreno-ceptor agonist that has analgesic and sedative propties with little effect on ventilation.[Objective] This study want to investigate the influence of Dexmedetomidine in serum interleukin2(IL-2),and cortisol (cor)following Cervical Cancer Cured by Operation[Method] Forty ASA I-II women submitted to Cervical Cancer cured by operation carried out at Liaoning tumor Hospital between Oct 2010 and March 2011, age 47 to 73 years, were randomized and placebo-controlled to two groups of 20 individuals.They received either sevoflurane-fentany or sevoflurane-fentany-Dexmedetomidine anesthesia. (D) Dexmedetomidine group (n=20):infusion of 1μg/kg over 10 minutes and maintenance dose of 0.5μg/kg/h as an adjuvant to inhaled sevoflurane anesthesia; (N) Control group (n=20):normal saline infusion at a similar rate and volume of the dexmedetomidine infusion.After 10 minutes, IV propofol (2.0mg/kg), IV fentanyl (3μ/kg)and IV vacurium(0.08 mg/kg) were infused. Tracheal intubation was performed after three minutes. Group D:Anesthesia was maintained with sevoflurane with IV fentanyl and Dexmedetomidine. Group N:Anesthesia was maintained with sevoflurane with IV fentany1.For adequate surgical relaxation, subsequent doses of vacurium during maintenance of the intraoperative.During the anesthetic periods, groups were compared regarding heart rate, systolic and diastolic arterial blood pressures as well as need of supplemental sevoflurane and fentanyl infusion. The HR,SBP,DBP were recored at time points before induction (To), after ten minutes of IV dexmedetomidine (T1),the time of the end of intubation (T2),the time of two hours after operation beginning (T3) and after extubation (T4).The IL-2 and the venous blood of cor were recored at T0,T3,T4. Student's t test were used for statistical analysis.[RESULTS] Both groups were homogeneous in terms of age, weight, baseline hemodynamic parameters, the level of IL-2 and cor in To. Comparing both groups at the different moments, the heart rate decreased and systolic blood pressure in T1 increased significantly (p<0.05) in the group D compared to the group N. The IL-2 decreased and cort in T4 increased significantly in the group N compared to the group D. In the group D the heart rate obviously decreased at T1 than To and the COR obviously increased at T4 than To. In group N the heart rate obviously increased at T4 than To and the COR obviously increased at T4 than To, and the IL-2 obviously increased at T4 than To. When compared to group N, the use of dexmedetomidine did reduce the need for supplemental doses of fentanyl and sevoflurane for maintenance of hemodynamic parameters during the intraoperative period.[CONCLUSION] We find that General anesthesia combined with dexmedetomidine may improve HR stability and reduce the stress reaction of the extubation. It does not significantly reduce the IL-2.Dexmedetomidine may reduce the need for supplemental doses of fentanyl and sevoflurane.