Expression And Clinical Significance Of HIF-1α, HIF-3α In Renal Cell Carcinoma

Objective: To explore the expression and clinical significance of HIF-1α(hypoxia inducible factor-1α) and HIF-3α(hypoxia inducible factor-3α) in human renal cell carcinoma (RCC).Methods: Immunohistochemistry was employed to determine the expressions of HIF-1αand HIF-3αin 49 cases of renal tissues with RCC and 9 cases of normal renal tissues.Results: Immunohistochemistry staining for HIF-1αwas noted in the nucleus of RCC. The expression rate of HIF-1αin RCC is 77.6% (38 cases of RCC were involved), which was increased more significantly than normal renal tissues group (P<0.05). The expression rate of HIF-3αin RCC is higher than normal renal tissues group (P<0.05). Lymph node metastasis and distant metastasis can affect the expression of HIF-1α. The relationship between the expression of HIF-1αand HIF-3αin RCC showed negative rank correlation (rs=-0.492, P<0.01).Conclusion: Our results showed that the expression rate of HIF-1αin human renal cell carcinoma was strong related with clinical stages, pathologic tumor stage, lymph node metastasis, and metastasis. It might be the important biological marker in renal cell carcinoma. HIF-3αcan affect the expression of HIF-1αin RCC , it might be a potential target against RCC within targeting treatments.