Application Of Mesoporous Silica Nanoparticles On Drug Delivery

Mesoporous silica nanoparticles (MSN) , Which has high surface area, controllable pore structure, functional surface, good biocompatibility, show broad application prospects in the biomedical field, especially in drugs delivery. High surface area is one of the advantages, which can bring about high loading capacity can be increased effectively. In addition to the characteristics of the material itself, the load conditions can affect the drug loading amount significantly. The ideal load conditions can increase efficiency of the drug carrier and reduce the side effect might brought by the carrier.Currently, the research of MSN drug delivery system has focused on the development of "smart" carrier"of the development of drugs, which can benefit the controlled released and drug target. And the studies usually base on the common used "probe drug", however the delivery of some drugs that has a good effect on certain diseases have been seldom done. What's more there also lack the study of the loading mechanisms.In this paper, we studied the loading and release mechanisms. We loaded some drugs that lack of ideal carriers into MSN, and have chosen ideal loading conditions. Finally, we realized co-delivery using MSN.First, we loaded DOX into MSN. Through the researches on the modifications, loading conditions, loading media, we achieved a high DOX loading amount at 250mg/g. And by fitting the results with classical models, we analyzed the loading mechanisms. Then we used amino-MSN loaded NAD+ successfully based on coordination bond, and achieved a high loading amount at 440mg/g. we also studied the effects of adsorption media and metal ions on the loading amount. The pH-responsive release behaviors were also been studied.Second, we loaded Rapamycin into mesopores. By studying the effect of polarity and hydrogen bond of the media on the adsorption amount, we have chosen CCl4 as adsorption media and the loading amount is 124mg/g. We also studied the release behavior of Rapamycin.Finally, we loaded DOX and Rapamycin in order to achieve the synergistic drug effects. We studied the dependence of Rapamycin loading amount on the loading amount of DOX as well as the DOX release behaviors of the co-delivery system. And we found the co-loading system showed better results of killing tumor cell.