EA Fenglong Intervention Hyperlipidemia Experimental And Clinical Study

ObjectivesHyperlipidemia is Chinese medicine, "phlegm""Blood"Category, General performance of clinical hypercholesterolemia, hypertriglyceridemia or mixed hyperlipidemia (both)。Hyperlipidemia atherosclerosis is the primary risk factors, and coronary heart disease, cerebrovascular disease incidence has a direct correlation. Therefore, prevention and treatment of hyperlipidemia is particularly important.In recent years, some studies have shown that acupuncture can effectively regulate Fenglong blood lipid levels of hyperlipidemia. In this project, based on previous studies, further experimental and clinical aspects from EA Fenglong prevention of hyperlipidemia and its possible clinical efficacy of the mechanism.MethodsFed high-fat animal feed produced by hyperlipidemic hamster model, we observed the EA Fenglong in hyperlipidemic hamster blood lipid levels, as well as LCAT, HMG-CoA, LDL-R activity Effects. Observation of clinical studies in patients with hyperlipidemia sputum of 66 cases,4 patients dropped out, and ultimately for the 62 patients, both Chinese and Western Medicine Hospital of Wuhan acupuncture, endocrinology, cardiology inpatient and outpatient, divided into two groups according to laboratory serum lipids:the hypercholesterolemia group (A group) and 30 patients with hypertriglyceridemia group (B group),32 cases, course of 28 days, on the A, B Hong Leong group were treated with acupuncture points treatment, after treatment, the clinical efficacy comparison between the two groups.Results1. animal experimental study:(1) model group hamster serum TC, TG, LDL-C level was significantly higher than the normal group, the difference was statistically significant (P<0.01), HDL-C levels were significantly lower than the normal group The difference was statistically significant (P<0.01); electric acupuncture group, western medicine, acupuncture prevention group, western medicine prevention group hamster serum TC, TG, LDL-C levels were significantly lower than the model group, the difference was statistically Significance (P<0.01), HDL-C levels were significantly higher than the model group, the difference was statistically significant (P<0.01); electric acupuncture group, western medicine hamster serum TC, TG, LDL-C, HDL-C levels did not change significantly the difference was not statistically significant (P> 0.05); EA prevention group, western medicine prevention group hamster serum TC, TG, LDL-C, HDL-C levels did not change significantly the difference was not statistically Significance (P> 0.05). (2) model group hamster serum LCAT, LDL-R expression level was significantly lower than the normal group, the difference was statistically significant (P <0.01), HMG-CoA activity was significantly higher than the normal group, the difference was statistically significant (P<0.01); electric acupuncture group, western medicine, acupuncture prevention group, western medicine prevention group hamster serum LCAT, LDL-R expression was significantly higher than the model group, the difference was statistically significant (P <0.01), HMG-CoA activity was significantly lower than the model group, the difference was statistically significant (P<0.01); electric acupuncture group, western medicine hamster serum LCAT, HMG-CoA, LDL-R expression did not change significantly the difference was not Statistically significant (P> 0.05); EA prevention group, western medicine prevention group hamster serum LCAT, HMG-CoA, LDL-R expression did not change significantly the difference was not statistically significant (P> 0.05).2. Clinicalstudy:(1)hypercholesterolemia, hypertriglyceridemia group and symptom scores before and after treatment were reduced compared with before treatment, the difference was significant (P<0.01); the abundance EA Long points lower in patients with hypercholesterolemia integral role in the clinical signs than hypertriglyceridemia group, the difference was significant (P<0.05). (2) efficacy of Chinese medicine and laboratory test results in terms of efficacy, acupuncture points lower Hong Leong group of patients with hypercholesterolemia, hypertriglyceridemia group was higher than that.Conclusions1. Electroacupuncture Fenglong effective prevention of hyperlipidemia, to reduce hyperlipidemia hamster TC, TG, LDL-C, HDL-C lipid levels, mainly through the enhancement of its way to LCAT, LDL-R activity Reduce the activity of HMG-CoA to complete.2. For patients with hypercholesterolemia and hypertriglyceridemia in patients with EA Fenglong, regardless of symptom points from the Chinese point of view, or from the laboratory TC, TG, LDL-C, HDL-C levels of blood lipids Of view, the effect of the former than the latter. EA Fenglong that can reduce high cholesterol better blood lipid levels.