| Objective:This study aimed to investigate the methotrexate, mifepristone combined Huayuxiaozhengtang Integrative Medicine Clinical efficacy of conservative treatment of medication.Methods:1. Selected parts of pregnancy after cesarean section uterine scar 25 patients, for September 2008-2010 in December between Chinese medicine hospital in Hubei Province, Wuhan First Hospital inpatient gynecology ward patients, all patients were diagnosed with the relevant examination CSP. TCM Evidence for the lower abdomen and blood stasis. Voluntary choice by the treatment of patients will be divided into 25 patients in the combination therapy group 13 cases, Western medicine alone control group of 12 cases. Two groups were age, menopause days from the last time cesarean section, past medical history, including fast size, size and value of the blood HCG TCM was no significant difference between cases (P> 0.05) were.2. Groups herein are methotrexate (Jiangsu Hengrui Medicine Co. Ltd., Approval Number:Zhunzi H-32026197) 50mg, in the abdomen by transvaginal ultrasound-guided puncture pregnancy sac single injection, while oral administration of non-rice Mifepristone (Hubei Gedian Humanwell Pharmaceutical Co., Ltd., Approval Number: Zhunzi H-20040365) 50mg,1 time / 12h,empty stomach, a total of 6 times, the treatment group while taking the medicine circulation Xiaozheng soup Day one, decoction 200ml, twice taking. Basic side as follows:TCS 15g, Salvia 12g, red peony root 12g, peach kernel 12g, angelica 12g, Tri-6g, Curcuma 6g, centipede 2, Lithospermum 10g, paeonol 9g, licorice 6g. With the addition and subtraction cards:abdominal pain were added fumarate, turmeric; increase the amount of bleeding is greater notoginseng, fried Puhuang; loss of appetite were increases Gallus gallus domesticus; nausea and vomiting with ginger Pinellia.2 during treatment require date of inspection in the blood HCG, the first day of ultrasound examination 5. Observed at the same time as life safety signs, symptoms, side effects, blood, liver and renal function. After treatment, follow-up.3. Evaluation Standard:clinical cure:Blood HCG decreased progressively, returned to normal within 15 days after treatment, B-Tip scar packages continue to shrink soon after treatment, and disappeared within 30 days, vaginal bleeding less than 15 days, no Abdominal pain, cervical back to normal, clinical symptoms and signs disappeared. Markedly:Blood HCG decreased progressively after treatment returned to normal within 15 days or 15 days after treatment, did not return to normal, back to normal after 30 days of review, B-Tip scar packages continue to shrink soon after treatment, but the package quickly disappeared more time 30 days, less than 15 days of vaginal bleeding, no pain, clinical symptoms and signs disappeared. Invalid:not satisfied with a drop of blood HCG (HCG drop of blood, time check<20%) or blood HCG continued to rise, not fall or, B-Tip scar significantly smaller packages or packages not fast fast increase of the net is not dripping vaginal bleeding More than the amount of menstrual flow or bleeding, abdominal pain.4. Statistical analysis methods:statistical software SPSS18.0 data applications is analyzed. Rank by Ridit analysis, count data using X2 inspection, measuring data by T test data.Results:1.The treatment group,13 were healed in 9 cases, effective in 2 patients,2 patient, the total efficiency of 84.62%; control group, 12 cases were cured in 5 cases, markedly effective in 1 case,6 cases, total effective rate 50.00%. The total effective rate was not statistically significant difference (P>0.05).2. The treatment group in make blood HCG decline, pregnancy and bag piece narrowing, bag piece disappeared time etc its curative effect compared with controls difference was statistically significant (P< 0.05).3. Treatment group and control group were less systemic adverse reactions, two sets of results were not statistically significant difference (P>0.05).Conelusion:This topic research suggests methotrexate and remove blood stasis away disease soup combined mifepristone influences treatment after cesarean section uterine scar parts is effective and safety in pregnancy, and better therapeutic methotrexate joint mifepristone influences. Its mechanism may and improve blood rheology, promote blood clots, kill embryos, decompose absorption inflammation, antibacterial, acetanilide, regulate immune function and so on. Therefore, we should play to the advantage of combining traditional Chinese and western medicine treatment, the greatest degree of the body of a patient health. |
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