The Relationship Between Mcm7 And Cdc6 Expressing In Breast Carcinoma And Their Clinicopathological Significance

Objective: To investigate the expression of Mcm7mRNA and Cdc6mRNA in human breast carcinoma tissues, and to explore the association between the expression of Mcm7mRNA, Cdc6mRNA and clinicopathological features in breast carcinoma. And reveal their relationship with biological behavior and prognosis of breast carcinoma.Methods: The reverse transcription-polymerase chain reaction (RT-PCR) technique was used to examine mRNA expression of Mcm7 and Cdc6 in 78 pairs specimens of breast carcinoma and normal tissues adjacent carcinoma. To explore the association between the expression of Mcm7mRNA, Cdc6mRNA and clinicopathological features in breast carcinoma.Results: The positive rates of Mcm7mRNA and Cdc6mRNA (85.90%, 69.23%) were higher in breast carcinoma tissues than (41.03%, 35.89%) in tissues adjacent carcinoma respectively (p<0.05). While the co-expression rate of Mcm7mRNA and Cdc6mRNA was 75.64%. Mcm7mRNA expression was correlated with lymph node metastasis, age group, pathological stage and ki-67(p<0.05). No correlation was found with the other clinicopatholagical features of breast carcinoma (p>0.05). Cdc6 expression was correlated with pathological stage, histological grade, lymph node metastasis (p<0.05). And there was no correlation with the other clinicopathological features of breast carcinoma too (p>0.05).Conclusion: Mcm7mRNA and Cdc6mRNA were expressed higher inhuman breast carcinoma. Mcm7 and Cdc6 may play a crucial role in oncogenesis, development, metastasis and relapse of breast carcinoma. Their cooperation may promote the process. They can be used as prognostic markers of breast carcinoma in clinical practice.