Bones Capsule The Treatment Of Primary Osteoporosis Clinical Research

ObjectivesThis topic proposed by syndromes bone mineral density (BMD) effect assessment, compared, estradiol (E2), testosterone(T),osteocalcin (BGP), serum alkaline phosphatase (ALP), hydroxyproline (HYP), urinary calcium (U-Ca), plasma fight tartaric acid salt acidic phosphatase (TRAP), parathyroid hormone (PTH), of calcitonin (CT), blood calcium (S-Ca) and phosphate (S-P) index variation to observe bones capsule the treatment of primary osteoporosis (POP), and further explore the clinical curative effect of the pathogenesis and POP for strong bones and muscles, hepatorenal, spleen yiqi, promoting blood circulation to remove blood stasis control mechanism, the preliminary POP to relieve pain and improve clinical efficacy and clinical promotion offered the thought.Methods1. Randomized, double-blind, parallel comparison experimental methods:All qualified participants are fromhubei xiangyang city outpatient department and the inpatient orthopaedic hospital of traditional, were 80 cases of patients, randomized, double-blind, divided into the treatment group (bones capsule group) and the control group (western medicine le force capsule group),40 cases in each group.2. Experimental drugs:The control group choose joy force capsule; The treatment group selection, two capsules bones capsule pharmaceutical preparation, unified packaging appearance by marking for bones, and Numbers. No.ⅠAccording to Numbers and corresponding with drug dosing:every time six Numbers to grain,3 times a day, eat hind half an hour take, 1 months for a period of treatment, after treated for 6 cycles statistical curative effect.3. Outcome measures:Before treatment with two groups of gender, age, duration, syndrome type, basic diseases, clinical integral and other basic material were compared by statistical analysis, no significant difference (P>0.05), explain two groups of comparable. After the treatment effect assessment according to syndromes bone mineral density (BMD), comparative, estradiol (E2), testosterone (T), osteocalcin (BGP), serum alkaline phosphatase (ALP), hydroxyproline (HYP), urinary calcium (U-Ca), plasma fight tartaric acid salt acidic phosphatase (TRAP), parathyroid hormone (PTH), of calcitonin (CT), blood calcium (S-Ca) and phosphate (S-P) index variation to assess the statistical analysis of the drug's effectiveness evaluation.4. Statistical analysis:After the end of experiment statistical analysis, using statistical analysis software spssl3.0. Level Ridit inspection, measuring data use data are in s said significant test using t-test, counting material adopt u inspection and x2 inspection. P<0.05 will be considered by the testing of a statistically significant difference.Results1. The total curative effect comparison:treatment group powerfully in 12 cases, effective 26 cases, invalid 2 cases failure; the total effective 95%; The control group,10 cases were effective got 27 cases, invalid 3 cases failure; the total effective Ridit inspection, the joys, P>0.01, explain two groups of clinical comprehensive effect no significant differences.2. Compare syndromes curative effect of two groups drugs original hairstyle osteoporosis patients total effective syndromes are statistically significant comparative, (P<0.05), indicating that the treatment group to improve syndromes than control group.3. The effect on bone mineral density BMD after treatment:treatment group than before treatment improved, a statistically significant (P<0.05). The control group BMD improved after treatment, also have significant difference (P<0.05). But the increase of treatment group was better than control BMD, two groups in treatment group contrast BMD after a statistically significant (P<0.05). The conclusion shows that the treatment group for strong bones and muscles in the kidney, and enriching qi, promoting blood circulation to remove blood stasis of traditional Chinese medicine composition have increased BMD, prevent bone loss function.4. The influence of bone formation, the two groups after treating ALP, improved obviously BGP before treatment, and with significant difference (P<0.01); The control group after treatment improved BGP, ALP was statistically significant (P<0.05). Two groups of comparisons, the treatment group in the improvement of bone formation than in control group (P<0.05), indicating that the treatment group have promote bone formation action.5. The influence of bone resorption, two groups after treating U-Hyp/Cr, U-Ca/Cr, TRAP, and were significantly drop before treatment with significant difference (P<0.05) two groups of comparisons, the treatment group in the improvement of bone formation than in control group (P<0.05), indicating that the treatment group have inhibit bone absorption effect.6. The effect of calcium metabolism:two groups after treating CT, S-Ca were markedly improved (P<0.05). Comparison between the two groups in treatment group increased calcium uptake, improve bowel blood calcium concentration improved better than control group in better than control group (P<0.05). Both groups were obviously decreased after treatment with PTH before treatment, with significant difference (P<0.05). Two groups of comparisons, the treatment group prevent bone calcium dissloution better than the control group (P<0.05). The two groups after treating S-P (P> 0.05) not significantly affect the metabolism of phosphorus.7. The influence of sex hormones two groups after treatment were more treatment,T, E2 improved before, but this was not statistically significant (P>0.05).8. The influence of safety index:two groups of patients blood and urine and kidney function, conventional, dung electrocardiogram (ecg) were not significantly abnormal.ConclusionResearch shows that bones capsule for POP alopecia kidney bones, is to remove stasis, can significantly improve syndromes, increase in bone density, and clinical use indices such as non-toxic side effects, is worth popularizing.