Peng E-zhu Volatile Oil Microemulsion Drug-loading System Research

Mecroemulsion is by oil phase, water phase, emulsifier and auxiliary emulsifier spontaneously formed in the appropriate proportion of a kind of transparent or translucent, low viscosity, isotropic grease mixing system. Mecroemulsion is thermodynamics and kinetics are very stable system, not affected by temperature, time, concussion and pH value, the influence of such factors as can always keep uniform transparent liquid state。At present, the main function is to micro breasts, and can be used for drug carrier oral liquid dosage forms, dermal medication preparation, eye ophthalmic preparation and injection. Its main has the following advantages:is isotropic transparent liquid, thermodynamic stability, and can filter, easy preparation and save; Can also increase soluble different fat-soluble drugs; Drug good dispersion, which will help absorb, can improve the bioavailability of drugs; Water-soluble drugs can prolong the time of release; Can be made into various forms, including oral agents, injection preparations and transdermal preparations. For easy hydrolysis, using the drugs can be considered water microemulsion protect; Size is small, can effective and fast through the gastrointestinal epithelium cells, thus greatly improve the bioavailability of drugs; Prescription once determined, the preparation methods simple.Zingiberaceae plants shows the rhizome is dry. Its effect for good gas broken blood, blood, attending away product pain and flatulence, dyspepsia amenorrhoea, early cerical cancer anticancer, anti-inflammatory, antibacterial, functions. The active ingredient in the volatile shows, for is 1% to 2.5% content. Modern research has shown, shows that oil has antitumor effect, can inhibit tumor abnormal cellular proliferation. Different varieties, different origin, shows that volatile already respectively identified 29 to 42 compounds, mainly for terpenoids and half terpene derivatives. One of the effects can inhibit alcohol in a test tube staphylococcus aureus, escherichia coli, typhoid bacillus, etc, the growth of respiratory syncytial virus have direct inhibition of influenza virus, have direct knockout action, mainly used in the clinical treatment of cervical cancer in the air, but easy oxidation, illumination can decompose and affect its curative effect.The experiment shows that the effect of oil according to develop with Mecroemulsion for drug-loading system, improve the stability and shows the bioavailability. Extracted from different process shows that volatile, choose the best method. And then by gc-ms combination measure its constituents content, finally to the stability test shows that oil is developed breasts. Shows oil micro Through the method of drawing ternary phase diagram, choosing the appropriate micro emulsion preparation, preparation of the twain-shows that volatile 80/ethanol/nutmeg acid of isopropyl/water 0/W type micro emulsion. But also inspects temperature, salt, PH and and high-speed centrifugal acceleration test the effect on the stability of the breasts of micro.