Hand, Foot And Mouth Disease Pathogenic Immune And Clinical Pathogenesis

Background and PurposeHand, foot and mouth disease (HFMD) is a pediatric infectious disease caused by enterovirus. The main clinical manifestations of HFMD are infections of hand, foot and mouth. A small number of sick children would suffer from complications such as myocarditis, pulmonary edema and aseptic meningoencephalitis and few severe ones would cause death. Own to the regional outbreak of HFMD recently, more and more attention is drawn to the detriment of it. However, in the present medical system especially in the basic level hospitals, systematic research on the pathogenic immunity and clinical pathogenesis of HFMD is highly inadequate. Therefore, this study investigated the viral infection of HFMD in Liaocheng region in the last two year.Methods and Results1. Serological detection showed that in 5724 suspected cases from 2009.1.1 to 2010.12.31,4453 cases were EV-U positive.2. Virus isolation and PCR identified the viral pathogen of HFMD.3. Flow cytometry analysis revealed that the ratio of lymphocyte subsets of the sick children varied in the period of illness.4. Comparison between common cases and severe cases in the clinical therapy showed that the occurrence of HFMD is related to the infectious background, prognosis and individual differences, which deserves further thorough investigation.ConclusionDealing with the HFMD pathogen transmission and prevalence, it should take prevention and disease control management as soon as possible. The occurrence of HFMD in one region almost appears in the same virus strain infection. Most common cases present quick-occurring and self-repairing characteristics. The occurrence of severe cases is closely related to the immune state of the sick children and the treatment time.